Results 101 to 110 of about 26,435 (315)

Design and analysis of a stiffened composite fuselage panel [PDF]

open access: yes
The design and analysis of stiffened composite panel that is representative of the fuselage structure of existing wide bodied aircraft is discussed. The panel is a minimum weight design, based on the current level of technology and realistic loads and ...
Biggers, S. B., Dickson, J. N.
core   +1 more source

Biodegradable Carbonate Nanogels Loaded with Anti MFAP‐5 siRNA for Anti‐stromal Therapy of Hepatocellular Carcinoma

open access: yesAdvanced Science, EarlyView.
Polycarbonate nanogels enable lipid‐free delivery of anti‐MFAP‐5 siRNA into cancer‐associated fibroblasts (CAF) in hepatocellular carcinoma. In a cirrhotic murine model, this approach silences MFAP‐5, reduces fibroblast activation, and suppresses tumor growth by inhibiting NOTCH/Hes1‐driven angiogenesis. CAF‐targeted MFAP‐5 RNAi and conserved signaling
Paul Schneider   +20 more
wiley   +1 more source

A metal sheet stiffened by a partially debonded composite quarter-plate [PDF]

open access: yes
An isotropic sheet stiffened by means of an orthotropic quarter-plate is considered. The quarter-plate is assumed to be perfectly bonded to the metal sheet everywhere except an area of debonding which may develop due to high stress concentrations.
Arin, K.
core   +1 more source

In Situ Characterisation of Hydrogels via Dynamic Interface Printing

open access: yesAdvanced Science, EarlyView.
ABSTRACT Hydrogels have become pivotal materials for tissue engineering, robotics, biomedical devices, and sensing applications due to their diverse material compositions and tunable mechanical properties. While significant effort has focused on developing novel manufacturing approaches such as extrusion bioprinting and light‐based fabrication methods,
Callum Vidler   +2 more
wiley   +1 more source

Improvements to a method for the geometrically nonlinear analysis of compressively loaded stiffened composite panels [PDF]

open access: yes
This report describes progress made during the period July 1991 to December 1991 on the tasks identified in the technical proposals for the subject grant. The plans for further effort on each of the tasks are outlined.

core   +1 more source

Timing Mechanotransduction: Mechanically Dynamic Biomaterials Reveal the Temporal Hierarchy of YAP/TAZ Control Nodes

open access: yesAdvanced Science, EarlyView.
This work develops dynamically softening polyacrylamide hydrogels for time‐resolved imaging during continuous mechanical transitions. The study revealed that mechanotransduction is biphasic; YAP/TAZ inactivation is driven by early loss of the nucleocytoskeletal continuum connecting subnuclear adhesions, F‐actin, and the nuclear envelope, coupled with ...
Alessandro Gandin   +12 more
wiley   +1 more source

Vibration analysis of stiffened plates using finite element method

open access: yesLatin American Journal of Solids and Structures
This paper presents the vibration analysis of stiffened plates, using both conventional and super finite element methods. Mindlin plate and Timoshenko beam theories are utilized so as to formulate the plate and stiffeners, respectively.
Shahed Jafarpour Hamedani   +2 more
doaj   +1 more source

An Insulin‐Exosome‐TNFAIP8 Axis Drives Stromal Fibrosis and Therapeutic Resistance in Pancreatic Cancer

open access: yesAdvanced Science, EarlyView.
In pancreatic ductal adenocarcinoma (PDAC), insulin is associated with activation of PI3K/AKT–RAB3A signaling and enhanced secretion of TNFAIP8‐enriched exosomes from tumor cells. Uptake of these exosomes by fibroblasts is linked to TRIM21‐dependent STAT1 degradation and the emergence of myofibroblastic CAF–associated features, accompanied by increased
Zhenyu Li   +15 more
wiley   +1 more source

Parametric study on average stress-average strain curve of composite stiffened plates using progressive failure method

open access: yesLatin American Journal of Solids and Structures
The post-buckling behavior of composite ships' stiffened plate panels has been studied. In this study, the average strain- average stress curves for these panels are derived using progressive failure method as well as nonlinear finite element method. The
Fattaneh Morshedsolouk   +1 more
doaj   +1 more source

User's manual for MacPASCO [PDF]

open access: yes
A user's manual is presented for MacPASCO, which is an interactive, graphic, preprocessor for panel design. MacPASCO creates input for PASCO, an existing computer code for structural analysis and sizing of longitudinally stiffened composite panels ...
Davis, R. C., Lucas, S. H.
core   +1 more source

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