Results 111 to 120 of about 26,435 (315)

Hepatocyte PIEZO1 Negatively Regulates Lipogenesis and Ameliorates MASLD by Sensing Membrane Tension and Activating AMPK

Advanced Science, EarlyView.
Hepatocytes are subjected to increased membrane tension along with lipid accumulation. Loss of PIEZO1 exacerbates high‐fat diet‐induced MASLD in mice. Activation of PIEZO1 alleviates high‐fat diet‐induced MASLD in mice. PIEZO1 negatively regulates de novo lipogenesis through activation of CaMKK2‐AMPK pathway. ABSTRACT Liver is a central organ for lipid
Hui Chen, Qimeng Wang, Ke Yang, Qinghai Lian, Xuyun Peng, Zhiyong Gong, Xinyi Zhao, Yong Wu, Tian Tao, Siqi Xu, Yifan Chen, Xiaoyan Tang, Jinghui Guo, Geyang Xu, Qi Zhang   +14 more
wiley   +1 more source

An investigation of the parametric resonance of rectangular plates reinforced with closely spaced stiffeners [PDF]

Parametric resonance and structural stability model of uniformly reinforced flat ...
Duffield, R. C., Willems, N.
core   +1 more source

Mechanical Overloading‐Induced Nanomineral Crystal Perturbation from the Osteochondral Interface: A Potential Initiator of Osteoarthritis

Advanced Science, EarlyView.
Laser‐induced graphene (LIG) provides a scalable, laser‐direct‐written route to porous graphene architecture with tunable chemistry and defect density. Through heterojunction engineering, catalytic functionalization, and intrinsic self‐heating, LIG achieves highly sensitive and selective detection of NOX, NH3, H2, and humidity, supporting next ...
Nan Jiang, Rong Ren, Zhan Su, Jiahao Zhou, Pinyin Cao, Sicheng Zhang, Zhen Li, Chao Li, Songsong Zhu   +8 more
wiley   +1 more source

Effects of Partial Edge Loading and Fibre Configuration on Vibration and Buckling Characteristics of Stiffened Composite Plates

Latin American Journal of Solids and Structures
In this work, the influence of uniaxial and biaxial partial edge loads on buckling and vibration characteristics of stiffened laminated plates is examined by using finite element method.
T. Rajanna, Sauvik Banerjee, Yogesh M. Desai, D. L. Prabhakara   +3 more
doaj   +1 more source

Vibrations and structureborne noise in space station [PDF]

Analytical models were developed to predict vibrations and structureborne noise generation of cylindrical and rectangular acoustic enclosures. These models are then used to determine structural vibration levels and interior noise to random point input ...
Bofilios, D. A., Lyrintzis, C. S., Vaicaitis, R.   +2 more
core   +1 more source

A Strain Decoupling Packaging Strategy for High‐Fidelity Ultrathin Silicon Shape Sensors for Soft Medical Robotics

Advanced Science, EarlyView.
Reliable soft sensors are essential for precise control in soft medical robots such as endoscopes. We developed ultrathin silicon piezoresistive sensors and their oil‐lubricated slidable packaging, which enables high‐fidelity shape sensing of silicon gauges by mechanically isolating the sensing element within a dual‐layer film.
Hao Liu, Masahito Takakuwa, Michitaka Yamamoto, Yiwen Wang, Tomoyuki Yokota, Takao Someya, Toshihiro Itoh, Seiichi Takamatsu   +7 more
wiley   +1 more source

Concurrent Topology Optimization of Curved-Plate Structures with Double-Sided Stiffeners

Mathematics
Due to their high specific stiffness, particularly in bending, along with their strong design capabilities, stiffened plates have become a prevalent structural solution in aerospace and various other fields.
Kai Xu, Fengtong Zhang, Yunfeng Luo, Quhao Li   +3 more
doaj   +1 more source

Composite reinforced propellant tanks [PDF]

Design studies involving weight and cost were carried out for several structural concepts applicable to space shuttle disposable tankage. An effective design, a honeycomb stabilized pressure vessel, was chosen.
Aleck, B. J., Brown, L. D., Landes, R., Martin, M. J.   +3 more
core   +1 more source

Bone Organoids: A Novel Tool for Modeling and Managing Skeletal Disorders in Diabetes

Advanced Science, EarlyView.
This review synthesizes advances in bone organoid engineering and evaluates their potential to model diabetic bone fragility. Current in vitro and animal models do not fully recapitulate diabetes‐associated skeletal phenotypes. Cell‐based and scaffold‐based bone organoids are discussed as complementary approaches to reconstruct multicellular bone ...
Shuangzhe Lin, Karthikeyan Narayanan, Deepak Vashishth   +2 more
wiley   +1 more source

STUDY ON ESTIMATION METHOD OF TENSILE STRENGTH OF AIRCRAFT STIFFENED-WELED PLATE

Jixie qiangdu, 2019
This paper studied methods to predict the tensile strength of stiffened-welded plate structure for civil aircraft welding. Based on the law of elastic modulus in the composite material mechanics,a theoretical formula is proposed to estimate the tensile ...
BAI ChengZheng, SONG Xin, SHENG HongWei, SHEN Yang, ZHANG JiaZhen   +4 more
doaj