Results 131 to 140 of about 21,851 (314)
Endothelial PDGF Signaling Dysregulation Impairs Testicular Interstitial Homeostasis in Diabetes
Advanced Science, EarlyView.Testicular endothelial cells (TECs) function as central signaling hubs that coordinate interstitial homeostasis. Diabetes disrupts TEC‐derived PDGF signaling, silences the JUND‐MCL1 survival program in Leydig cells, and impairs peritubular function, leading to fibrosis and testosterone insufficiency.
Wenxiu Zhang +14 more
wiley +1 more source
Stresses in adhesively bonded joints: A closed form solution [PDF]
The plane strain of adhesively bonded structures which consist of two different orthotropic adherents is considered. Assuming that the thicknesses of the adherends are constant and are small in relation to the lateral dimensions of the bonded region, the
Aydinoglu, M. N. +2 more
core +1 more source
Advanced Science, EarlyView.An ultrasoft yet tough organohydrogel (AQGL) with 5800% stretchability and 14.3 kPa modulus is developed via a novel molecular chain lubrication strategy. It features optical transparency, drying/freezing (−40°C) tolerance, antibacterial activity, conductivity, self‐healing, and adhesiveness.
Si Wang +9 more
wiley +1 more source
Understanding Glioblastoma Dynamics Using 3D Organoids and Engineered Extracellular Matrix
Advanced Science, EarlyView.A modular in vitro glioblastoma multiforme (GBM) model combining patient‐derived glioma stem‐like cells (GSC) organoid with an engineered extracellular matrix (eECM) and endothelial co‐culture enhances differentiation and GBM associated gene expression.
Autumn McManis +7 more
wiley +1 more source
Composite transport wing technology development: Design development tests and advanced structural concepts [PDF]
Numerous design concepts, materials, and manufacturing methods were investigated for the covers and spars of a transport box wing. Cover panels and spar segments were fabricated and tested to verify the structural integrity of design concepts and ...
Griffin, Charles F., Harvill, William E.
core +1 more source
Advanced Science, EarlyView.This study investigates how CTCs survive varying shear stress during hematogenous metastasis. We uncover a self‐protection mechanism, by which non‐adherent CTCs adapt to high shearing milieu through accumulated cytoplasmic myosin‐mediated disruption of myosin‐actin binding, attenuating force transmission into chromatin to protect CTCs from shear ...
Cunyu Zhang +10 more
wiley +1 more source
Transient analysis using conical shell elements [PDF]
, 1973 The use of the NASTRAN conical shell element in static, eigenvalue, and direct transient analyses is demonstrated. The results of a NASTRAN static solution of an externally pressurized ring-stiffened cylinder agree well with a theoretical discontinuity ...
Goeller, J. E. +2 more
core +1 more source
Highly Aligned Bacteria Cellulose Yarn Aggregation for Energy Generation and Strain Sensing
Advanced Science, EarlyView.Although high‐performance bacterial cellulose fibers have attracted significant interest for wearable electronics, a self‐powered and high‐mechanosensitive design is still scarce for achieving an intelligent integrated system. Here, we demonstrate an innovative bio‐fabrication strategy to develop a core‐sheath yarn that features the ordered network and
Chong Gao +9 more
wiley +1 more source
A Location Method Using Sensor Arrays for Continuous Gas Leakage in Integrally Stiffened Plates Based on the Acoustic Characteristics of the Stiffener. [PDF]
Sensors (Basel), 2015 Bian X +5 more
europepmc +1 more source
Advanced Science, EarlyView.Laterally spreading tumors (LSTs) are precancerous colorectal lesions characterized by a flat morphology. This study reveals a mechanochemical pathway through which a soft matrix microenvironment diminishes spatial constraints in intestinal adenomas. This process promotes deficiencies in tight junction proteins, mediated by the mechanoreceptor ADORA2B ...
Jiamin Zhong +21 more
wiley +1 more source