CK2α Deficiency Drives Myocardial Fibrosis via Desmin‐Induced Mitochondrial Dysfunction
Advanced Science, EarlyView.CK2α preserves mitochondrial homeostasis by phosphorylating Desmin to recruit Cryab, ensuring proper filament assembly. CK2α deficiency disrupts this interaction, causing mitochondrial dysfunction, metabolic shifts, bioenergetic failure, and oxidative stress—ultimately establishing a pro‐fibrotic environment that drives cardiac fibrosis.
Canjie Ma +12 more
wiley +1 more source
Research on Residual Strength and Evaluation Methods of Metal Aircraft Stiffened Panel Structures with Perforations. [PDF]
Materials (Basel)Ren A, An T, Zhang T, Wang Y, Ma L.
europepmc +1 more source
A Piezo‐Mimetic Ionic Hydrogel Harnessing Joint Motion for Cartilage Repair
Advanced Science, EarlyView.A piezo‐mimetic ionic hydrogel converts mechanical deformation into bioactive ionic currents via stress‐induced asymmetric ion migration. Coupled with sustained Mg2+ release, this mechano‐electrochemical platform bridges mechanical loading and cellular signaling, enabling load‐adaptive stimulation and enhanced cartilage regeneration. ABSTRACT Articular
Chenyuan Gao +14 more
wiley +1 more source
Concrete Damaged Plasticity-Based Analysis of Damage and Stiffness Degradation in Cooling Tower Shells Under Spatially Variable Seismic Loading. [PDF]
Materials (Basel)Boroń P, Dulińska JM.
europepmc +1 more source
Advanced Science, EarlyView.This study identifies the mechanosensor PIEZO1 as a key factor in promoting acute myeloid leukemia progression and uncovers a ferroptosis defense system mediated by PIEZO1‐HIF1A‐SLC7A11 axis that is essential for leukemia stem cell maintenance. This ferroptotic defense system may represent a unique vulnerability for leukemia stem cells, providing a ...
Tiantian Zhang +10 more
wiley +1 more source
Surface Glass Fiber Hybridization for Enhanced Low-Velocity Impact Resistance in CFRP T-Stiffened Panels. [PDF]
Polymers (Basel)Yuan Y +5 more
europepmc +1 more source
Advanced Science, EarlyView.We present the MyoRobot 3.0, an advanced platform that combines high‐resolution imaging with automated mechanical testing to improve the accuracy of single muscle fibre analysis. The system tracks fibre diameter changes during stretch, preventing major stress miscalculations.
Michael Haug +5 more
wiley +1 more source
Numerical investigation of ultimate capacity enhancement in corrugated web steel beams with different stiffening configurations. [PDF]
Sci RepFouda A +3 more
europepmc +1 more source
Advanced Science, EarlyView.Strong‐yet‐ductile precipitation‐hardening alloys require novel microstructural complexity of precipitates in particularly at cryogenic condition, to constantly impart strain hardening of hard‐and‐brittle precipitates. The present work creates innovative structurally complex precipitates assembled with dispersed nanocores and a chemical‐heterogeneity ...
Shaohua Gao +9 more
wiley +1 more source
A numerical simulation approach for inflatable asymmetric geometries of orthotropic fabrics. [PDF]
Sci RepAbdelmaseeh ASA +2 more
europepmc +1 more source