Elastic Critical Resistance of the Simple Beam Grillage Resulting from the Lateral Torsional Buckling Condition: FEM Modelling and Analytical Considerations. [PDF]
Materials (Basel), 2023 Piotrowski R, Szychowski A, Vičan J.
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Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy
Advanced Science, EarlyView.Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong +5 more
wiley +1 more source
Geometrically nonlinear high-fidelity aerostructural optimization for highly flexible wings. [PDF]
Struct Multidiscipl OptimGray AC, Kennedy GJ, Martins JRRA.
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Study on In-Plane Initial Rotational Stiffness of Eccentric RHS Beam-Column Joints. [PDF]
Materials (Basel), 2023 Guo X, Li W, Xv Z.
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Advanced Science, EarlyView.In pancreatic ductal adenocarcinoma (PDAC), insulin is associated with activation of PI3K/AKT–RAB3A signaling and enhanced secretion of TNFAIP8‐enriched exosomes from tumor cells. Uptake of these exosomes by fibroblasts is linked to TRIM21‐dependent STAT1 degradation and the emergence of myofibroblastic CAF–associated features, accompanied by increased
Zhenyu Li +15 more
wiley +1 more source
Top-Down Design Approach of Lightweight Composite Battery Pack Enclosure for Electric Vehicles Based on Numerical Modeling and Topology Optimization. [PDF]
Polymers (Basel)Zhang X +7 more
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Advanced Science, EarlyView.Hepatocytes are subjected to increased membrane tension along with lipid accumulation. Loss of PIEZO1 exacerbates high‐fat diet‐induced MASLD in mice. Activation of PIEZO1 alleviates high‐fat diet‐induced MASLD in mice. PIEZO1 negatively regulates de novo lipogenesis through activation of CaMKK2‐AMPK pathway. ABSTRACT Liver is a central organ for lipid
Hui Chen +14 more
wiley +1 more source
Numerical study on the cyclic behavior of the stiffened steel plate shear walls containing sandwich panels with corrugated core. [PDF]
Sci RepZhang S, Zhang P, Wang S, Ghiasvand A.
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A Soft Robotic Model for Simulating Heart Valve Disease and Cardiac Interventions
Advanced Science, EarlyView.This paper introduces a fully synthetic fabrication methodology for a soft robotic, in‐vitro model of the left‐heart, complete with a functioning mitral valve apparatus. With a view towards patient‐specific modeling, we demonstrate physiological flow and pressure waveforms, tunable mitral valve function with clinical imaging compatibility, and its use ...
James Davies +14 more
wiley +1 more source
Chiral multi-curved shell metamaterials integrating compression-torsion and buckling mechanisms for ideal energy absorption. [PDF]
Nat CommunLiu CX +5 more
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