Results 241 to 250 of about 24,891 (361)

CK2α Deficiency Drives Myocardial Fibrosis via Desmin‐Induced Mitochondrial Dysfunction

Advanced Science, EarlyView.
CK2α preserves mitochondrial homeostasis by phosphorylating Desmin to recruit Cryab, ensuring proper filament assembly. CK2α deficiency disrupts this interaction, causing mitochondrial dysfunction, metabolic shifts, bioenergetic failure, and oxidative stress—ultimately establishing a pro‐fibrotic environment that drives cardiac fibrosis.
Canjie Ma, Jiali Jia, Juncong Lan, Jing Wang, Dan Rao, Lanlan Rao, Weibin Zhang, Dongpeng Wu, Jie Zhang, Gang Wang, Baohua Liu, Ying Ao, Zimei Wang   +12 more
wiley   +1 more source

The Influence of Wide-Directional Asymmetric Spraying on Machining Deformation of Aluminum Alloy Plates. [PDF]

Materials (Basel)
Li Y, Lin Z, Li Y, Li X, Zhu K, Yu M, Li Y, Yan H.   +7 more
europepmc   +1 more source

A study on fatigue crack propagation in longitudinal stiffeners of ship structures

, 2005
Teppei Okawa, Yôichi Sumi, Masashi Mohri, Yasumi Kawamura   +3 more
openalex   +2 more sources

A Piezo‐Mimetic Ionic Hydrogel Harnessing Joint Motion for Cartilage Repair

Advanced Science, EarlyView.
A piezo‐mimetic ionic hydrogel converts mechanical deformation into bioactive ionic currents via stress‐induced asymmetric ion migration. Coupled with sustained Mg2+ release, this mechano‐electrochemical platform bridges mechanical loading and cellular signaling, enabling load‐adaptive stimulation and enhanced cartilage regeneration. ABSTRACT Articular
Chenyuan Gao, Xinyu Wang, Zhifeng Wu, Xinya Zhang, Xiao Geng, Ti Zhang, Yue Wang, Hongwei Xia, Jun Zhang, Xianbo Qiu, Cuiru Sun, Yingjie Yu, Wenli Dai, Hua Tian, Qing Cai   +14 more
wiley   +1 more source

Experimentally investigating the structural capacity of slender web tapered built up plate girder with web opening. [PDF]

Sci Rep
Taher M, Ebid AM, Ibrahim SM, El-Aghoury MA.   +3 more
europepmc   +1 more source

Techniques to carry weight loads and resist against bending in conical shells, cases in Kashan [PDF]

, 2017
Danaiee, Ahmad, Korsavi, Sepideh Sadat
core  

PIEZO1 is Required for Acute Myeloid Leukemia Progression and Leukemia Stem Cell Maintenance via HIF1A‐SLC7A11 Axis‐Mediated Ferroptosis Defense

Advanced Science, EarlyView.
This study identifies the mechanosensor PIEZO1 as a key factor in promoting acute myeloid leukemia progression and uncovers a ferroptosis defense system mediated by PIEZO1‐HIF1A‐SLC7A11 axis that is essential for leukemia stem cell maintenance. This ferroptotic defense system may represent a unique vulnerability for leukemia stem cells, providing a ...
Tiantian Zhang, Ziyan Cao, Kexin Gao, Shuxin Yao, Yanbing Zheng, Manman Cui, Rong Yin, Guoqiang Han, Jin Hu, Chengyi Wang, Haojian Zhang   +10 more
wiley   +1 more source

Mechanical performance of negative-stiffness multistable bi-material composites. [PDF]

Acta Mech
Mehreganian N, Razi S, Fallah AS, Sareh P.   +3 more
europepmc   +1 more source

RIGIDITY REQUIREMENTS FOR LONGITUDINAL AND TRANSVERSE STIFFENERS OF PLATE GIRDERS UNDER SHEAR

, 1988
Ichizou Mikami, Tsunenobu DEGUCHI
openalex   +2 more sources

T‐Cell Exhaustion in the Tumor Microenvironment: Subcellular Dysfunction, Pan‐Cancer Characteristics, and Therapeutic Interventions

Advanced Science, EarlyView.
This study elucidates the mechanisms of subcellular multidimensional collapse in exhausted T cells. By specifically targeting the nucleus, mitochondria, and endoplasmic reticulum, strategic interventions can effectively remodel the compromised organelle network. This integrated approach drives comprehensive T cell resuscitation, ultimately establishing
Mingxing Wang, Wanhui Dong, Jian Chen, Zhangjie Zhou, Shujuan Fu, Tingting Wu, Haiyan Jiang, Zhiying Wang, Zhixian Zhong, Yi Zhong   +9 more
wiley   +1 more source