Whole‐Blood RNA Sequencing Profiling of Patients With Rheumatoid Arthritis Treated With Tofacitinib
Objective Patients with rheumatoid arthritis (RA) often fail to respond to therapies, including JAK inhibitors (JAKi), and treatment allocation is made via a trial‐and‐error strategy. A comprehensive analysis of responses to JAKi, including tofacitinib, by RNA sequencing (RNAseq) would allow the discovery of transcriptomic markers with a two‐fold ...
Chiara Bellocchi+11 more
wiley +1 more source
Determination of the anatomic communications among compartments within the carpus, metacarpophalangeal and metatarsophalangeal joints, stifle joint, and tarsus in llamas [PDF]
Stacy A. Semevolos, Rhian B Cope
openalex +1 more source
Chromatin, which organizes DNA, changes its structure to adapt to stress like high oxygen levels (hyperoxia), which can damage cells. Researchers developed a technique to observe these changes and found variability in how different parts of chromatin remodel.
Lauren Monroe+4 more
wiley +1 more source
Relationship Between Increased In Vivo Meniscal Loads and Abnormal Tibiofemoral Surface Alignment in ACL deficient Sheep is Varied [PDF]
Adeeb+45 more
core +1 more source
"Minerals, Openness, Institutions and Growth: An Empirical Analysis" [PDF]
Empirical evidence from a panel-data analysis indicates that a mineral resource curse exists for certain developing countries, but not for developed countries.
Halit Yanikkaya, James L. Butkiewicz
core
β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio+11 more
wiley +1 more source
Terror and instability: sanctions stifle Pakistani development [PDF]
Does Pakistan’s newfound independence signal a shift in foreign policy ...
Weinstein, Adam
core
The Effects of Epidural Deracoxib on the Ground Reaction Forces in an Acute Stifle Synovitis Model [PDF]
Priti S. Karnik+4 more
openalex +1 more source
The axolotl's remarkable regenerative abilities decline with age, the causes may include the numerous repetitive elements within its genome. This study uncovers how Ty3 retrotransposons and coexpression networks involving muscle and immune pathways respond to aging and regeneration, suggesting that transposons respond to physiological shifts and may ...
Samuel Ruiz‐Pérez+8 more
wiley +1 more source
Evaluation of equine scintigraphic stifle scans
N Hieber, H D Lauk, G Ueltschi
openalex +2 more sources