Results 151 to 160 of about 1,391,136 (279)

Loss of E3 Ubiquitin Ligase RINES via CpG Methylation Relieves Suppression of STAT3 and MYC, Facilitating Multiple Tumorigeneses

Advanced Science, EarlyView.
Dysregulated protein modifications drive tumorigenesis. RINES, an E3 ubiquitin ligase, represses tumor cell proliferation and metastasis by facilitating RING domain‐dependent, ubiquitin–proteasome‐mediated degradation of STAT3 and MYC, which consequently restrains cancer stemness and oncogenic progression.
Lili Li, Ka Man Ng, Xingsheng Shu, Xiaoxue Chai, Kai Yau Wong, Gopesh Srivastava, Anthony T.C. Chan, Wai Yee Chan, Qian Tao   +8 more
wiley   +1 more source

Ultrasound Imaging Modalities in the Evaluation of the Dog's Stifle Joint. [PDF]

Vet Sci
Karatrantos AT, Sideri AI, Gouletsou PG, Bektsi CG, Barbagianni MS.   +4 more
europepmc   +1 more source

Gm26550 Modulates Learning and Memory by Increasing IGF1 mRNA Expression and Stability in Nrf2−/− Mice

Advanced Science, EarlyView.
The present study shows that Nrf2 directly binds to the Gm26550 promoter, thereby activating Gm26550 transcription and increasing its expression. Mechanistically, Gm26550 promotes IGF1 expression by functionally antagonizing miR‐26a‐5p‐mediated repression and sequestering the RBP KHSRP, thereby enhancing hippocampal neuronal synaptic plasticity and ...
Hongfang Wang, Ziyao Wang, Dongyue Zuo, Zhaowen Su, Bowen Song, Jiamin Gao, Yizhou Zhang, Ruiting Zhao, Linjie Sun, Mengdi Li, Yirui Fan, Dandan Geng, Lei Wang   +12 more
wiley   +1 more source

Application of Deep Learning-Based Reconstruction to Magnetic Resonance Imaging of Canine Stifle Joint in Healthy Beagles: Achieving Enhanced Image Quality With Reduced Slice Thickness. [PDF]

Vet Radiol Ultrasound
Jin W, Noh D, Yamada K, Lee SK, Choi S, Lee K.   +5 more
europepmc   +1 more source

Joint motion studies of the normal and cranial cruciate ligament deficient stifle in large breed dogs

, 1991
Joint motion was measured for the intact and cranial cruciate (CCL) deficient stifle in five large breed dogs. A combined method using an instrumented spatial linkage (ISL) and radiophotogrammetry provided a sensitive method of measuring the three ...
Korvick, Donna Lee
core  

Overcoming Artificial Structures in Resolution‐Enhanced Hi‐C Data by Signal Decomposition and Multi‐Scale Attention

Advanced Science, EarlyView.
Deep‐learning‐based signal enhancement is an effective way to recover high‐resolution details from a low‐resolution chromatin contact map. However, due to computational challenges, existing methods commonly divide up the contact map into small patches and create artificial discontinuities at patch boundaries.
Qinyao Li, Kelly Yichen Li, Chiara Nicoletti, Stephen Kwok‐Wing Tsui, Pier Lorenzo Puri, Qin Cao, Kevin Y. Yip   +6 more
wiley   +1 more source

Comparative cadaveric study of needle and conventional arthroscopy techniques of the feline stifle joint. [PDF]

J Feline Med Surg
Koecher-Vodnarek CA, Helm J, Schnabl-Feichter E.   +2 more
europepmc   +1 more source

Sustainable Materials Design With Multi‐Modal Artificial Intelligence

Advanced Science, EarlyView.
Critical mineral scarcity, high embodied carbon, and persistent pollution from materials processing intensify the need for sustainable materials design. This review frames the problem as multi‐objective optimization under heterogeneous, high‐dimensional evidence and highlights multi‐modal AI as an enabling pathway.
Tianyi Xu, Tianshuo Wei, Yan Ge, Bo Peng, Yue Li, Maolin Wang, Peng Wen, Chao Yang, Ye Wei   +8 more
wiley   +1 more source

Radiographic evaluation of patellofemoral proportional mismatch in small-breed dogs with medial patellar luxation: Implications for stifle joint morphology and surgical planning. [PDF]

Vet World
Akaraphutiporn E, Kaewmahing K, Chunhasewee P, Fuengsil S, Chaiyaphan T, Wangdee C.   +5 more
europepmc   +1 more source

Physics‐Constrained Constitutive Learning of Rate‐Limiting Timescales for Efficient Hydrogen‐Based Direct Reduction for Green Steel Making

Advanced Science, EarlyView.
A conversion‐resolved constitutive framework is developed for the hydrogen‐based direct reduction of iron oxide pellets. Effective reaction and transport timescales are inferred directly from measured trajectories and mapped against operating conditions, pellet architecture, and composition. The analysis reveals how late‐stage transport control emerges
Anurag Bajpai, Barak Ratzker, Pasquale Cavaliere, Dierk Raabe   +3 more
wiley   +1 more source