Results 51 to 60 of about 4,403 (296)

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Interleukin-18 [PDF]

, 2003
Interleukin-18 (IL-18), a recently described member of the IL-1 cytokine superfamily, is now recognized as an important regulator of innate and acquired immune responses.
Gracie, J.A., McInnes, I.B., Robertson, S.E.   +2 more
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Defective iron supply for erythropoiesis and adequate endogenous erythropoietin production in the anemia associated with systemic-onset juvenile chronic arthritis. [PDF]

, 1996
peer reviewedSystemic-onset juvenile chronic arthritis (SoJCA) is associated with high levels of circulating interleukin-6 (IL-6) and is frequently complicated by severe microcytic anemia whose pathogenesis is unclear.
Barosi, G., Beguin, Yves, Cazzola, M., de Benedetti, F., Invernizzi, R., Martini, A., Ponchio, L., Ravelli, A., Rosti, V.   +8 more
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Acute liver transplantation in a 41-year-old male patient presenting symptoms of adult-onset Still's disease [PDF]

, 2011
L
Andrès E., Bywaters E.G., Coffernils M., Cush J.J., Fautrel B., Ishikawa M., Kadar J., Linde B., Mehrpoor G., Mert A., Motoo Y., Nemes B., Nemes B., Nemes B., Ogata A., Singh S., Still G.F., Taccone F.S., Takami A., Teran A., Yamaguchi M., Zhu G.   +21 more
core   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Effects of HLA-DRB1 alleles on susceptibility and clinical manifestations in Japanese patients with adult onset Still’s disease [PDF]

, 2017
BackgroundHLA-DRB1 alleles are major determinants of genetic predisposition to rheumatic diseases. We assessed whether DRB1 alleles are associated with susceptibility to particular clinical features of adult onset Still’s disease (AOSD) in a Japanese ...
Asano Tomoyuki, Eguchi Katsumi, Fujikawa Keita, Furukawa Hiroshi, Ito Tomoyuki, Iwanaga Nozomi, Izumi Yasumori, Kawakami Atsushi, Kobayashi Daisuke, Kobayashi Hiroko, Koga Tomohiro, Migita Kiyoshi, Nakamura Tadashi, Nonaka Fumiaki, Ohira Hiromasa, Sato Shuzo, Shimizu Toshimasa, Suzuki Eiji, Tohma Shigeto, Tsuchiya Naoyuki, Ubara Yoshifumi, Ueki Yukitaka, Umeda Masataka, Watanabe Hiroshi, Yamasaki Satoshi, Yashiro Makiko, Yasunami Michio, Yoshiura Koh-ichiro, 古川 宏, 土屋 尚之   +29 more
core   +2 more sources

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Noncaseating suppurative granulomatous lymphadenitis in adult onset Still’s disease – a diagnostic dilemma in a tuberculosis-endemic region: a case report

Journal of Medical Case Reports, 2018
Background Lymphadenopathy is not an uncommon presentation of adult onset Still’s disease: it is present in up to two thirds of patients with adult onset Still’s disease.
S. W. G. J. W. Chinthaka, R. L. Satarasinghe, S. Senanayake, W. A. P. S. R. Weerarathne, A. A. M. Anfaz, M. P. Deraniyagala   +5 more
doaj   +1 more source