Results 81 to 90 of about 67,536 (306)

Characteristics and temporal trends of EU teratological safety signals and information dissemination to healthcare professionals in the Netherlands—A contribution of the ConcePTION project

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Although regulatory responses to safety signals have been studied, pregnancy‐specific data and their dissemination to medical professionals remain unclear. This study examined the characteristics and temporal trends of teratological safety signals prompting the European Medicines Agency to implement risk minimization measures.
Yrea R. J. van Rijt‐Weetink, Rosanne E. Huisman, Jan‐Peter van Wieringen, H. J. M. J. (Ineke) Crijns, Florence P. A. M. van Hunsel, Anneke L. M. Passier, Sander Borgsteede, A. C. G. (Toine) Egberts, Laura M. Yates, Eugène P. van Puijenbroek   +9 more
wiley   +1 more source

Case‐malformed signal detection and prioritisation using EUROmediCAT data for pharmacovigilance in pregnancy

British Journal of Clinical Pharmacology, EarlyView.
Aim Many women take medications during pregnancy. However, the risk to the fetus from most medications is uncertain. Congenital anomalies are one of the leading causes of infant death and contribute to long‐term disability. Signal detection methods can be used to systematically identify possible medication–anomaly associations that require further ...
Hannah Johnson, Helen Dolk, Maria Loane, Christine Damase‐Michel, Joanne Given, Hedvig Nordeng, Jorieke E. H. Bergman, Iain Carey, Elly Den Hond, Ester Garne, Florence Rouget, Lea Bruneau, Isabelle Monier, Anke Rissmann, Mary O'Mahony, Miriam Gatt, Renée Lutke, Joanna Sichitiu, Elisa Ballardini, Alessio Coi, Clara Cavero Carbonell, David Tucker, Joan Morris   +22 more
wiley   +1 more source

Stillbirth in twin pregnancies in Stockholm County 2000-2021-A descriptive study.

PLoS ONE
IntroductionThe incidence of stillbirth is higher in twin pregnancies compared with singleton pregnancies. Known risk factors for stillbirth in twin pregnancies include selective fetal growth restriction, twin-to-twin transfusion syndrome (TTTS) and ...
Matilda Varli Hjärne, Cecilia Pegelow Halvorsen, Hanna Åmark   +2 more
doaj   +1 more source

Maternal and foetal medical conditions during pregnancy as determinants of intrapartum stillbirth in public health facilities of Addis Ababa: a case-control study

The Pan African Medical Journal, 2019
INTRODUCTION: Globally, intrapartum stillbirth accounts for 1 million deaths of babies annually, representing approximately one-third of global stillbirth toll.
Alemayehu Gebremariam Agena, Lebitsi Maud Modiba   +1 more
doaj   +1 more source

Stillbirths: the vision for 2020

The Lancet, 2011
Stillbirth is a common adverse pregnancy outcome, with nearly 3 million third-trimester stillbirths occurring worldwide each year. 98% occur in low-income and middle-income countries, and more than 1 million stillbirths occur in the intrapartum period, despite many being preventable.
Goldenberg, Robert L., McClure, Elizabeth M., Bhutta, Zulfiqar A., Belizan, Jose M., Reddy, Uma M., Rubens, Craig E., Mabeya, Hillary, Flenady, Vicki, Darmstadt, Gary L.   +8 more
openaire   +6 more sources

Making real progress with stillbirth prevention

, 2020
The global burden of stillbirth has far‐reaching psychosocial impacts on women, families, caregivers and communities, and wide‐ranging economic impact on health systems and society.1 An estimated 2.64 million babies die after 28 weeks gestation but ...
Vicki Flenady, Ellwood, David, Flenady, Vicki, David Ellwood   +3 more
core   +1 more source

Tetraspanin‐ESCRT sorting drives miR‐29b packaging into extracellular vesicles to reverse fibrosis in intrauterine adhesions

BMEMat, EarlyView.
MiR‐29b is enriched in extracellular vesicles (EVs) via a tetraspanin transporter‐dependent endocytosis and sorting complex required for the endosomal transport (ESCRT)‐dependent pathway. These EVs target the 3′ untranslated region (3′UTR) of TGFB2, thereby inhibiting the TGF‐β/Smad3 signaling pathway and repairing endometrial damage in intrauterine ...
Lihao Chen, Jianfeng Wu, Shunhan Zhang, Siqi Huang, Yingjun Xie, Hongda Chen, Yinghong Yang, Lan Xiao, Ding Wang, Keke Wu, Xiaofang Sun   +10 more
wiley   +1 more source

Improving, But Could Do Better: Trends in Gestation-Specific Stillbirth in Australia, 1994–2015

, 2019
Stillbirth remains a large global problem in low- and middle-income settings but is also a public health concern in high-income countries. Over the past 20 years, stillbirth rates globally have shown little improvement and large disparities.
Georgina M. Chambers, Hilder, Lisa, Chambers, Georgina M, Donnolley, Natasha, Vicki Flenady, Lisa Hilder, Ellwood, David, David Ellwood, Flenady, Vicki, Natasha Donnolley   +9 more
core   +1 more source

Legal Professionals Use an Implicit Checklist to Assess Expert Witness Credibility

Behavioral Sciences &the Law, EarlyView.
ABSTRACT In a court of law, some forms of evidence are too technical to interpret without the help of an expert witness. However, expert testimony sometimes leads to wrongful conviction. We used an online survey to quantitatively compare how legal professionals (n = 122) and lay people (n = 109) understood what makes an expert witness credible.
Mahensingh Deonaran, Yvan I. Russell, Mandeep K. Dhami   +2 more
wiley   +1 more source

The trend and distribution of stillbirth in the Eastern Region of Ghana

Journal of Interventional Epidemiology and Public Health
Introduction: The trend of stillbirth in Ghana is on a slow decline from 22.5/1,000 total births in 2018 to 21.4/1,000 total births in 2021, and has not met its target.
Francis Asare Yeboah, Winfred Ofosu, John Ekow Otoo, Simon Adu-Poku, Delia Akosua Bandoh, Samuel Asare, Esther Berchie Osei, Michael Obodai Topson, James Forson, Ernest Kenu   +9 more
doaj   +1 more source