Results 81 to 90 of about 61,138 (307)

The role of IgM anti‐acetylated protein antibodies and B cells in the origin of anti‐modified protein autoimmunity in rheumatoid arthritis

Arthritis &Rheumatology, Accepted Article.
Objective Rheumatoid arthritis (RA) is characterized by anti‐modified protein antibodies (AMPAs), including anti‐citrullinated (ACPA), anti‐carbamylated (anti‐CarP), and anti‐acetylated (AAPA) protein antibodies. In contrast to other AMPAs, AAPA IgM is found in healthy individuals, raising questions about its role in early immune responses.
Aegli Athanasiadou, Sanne Kroos, Renee van de Wetering, Rian Schopmeijer, Carin van der Keur HLO, Michael Eikmans, Caroline Meijer, Solbritt Rantapää‐Dahlqvist, René E.M. Toes, Linda M. Slot, Diane van der Woude   +10 more
wiley   +1 more source

Identification of major congenital malformations based on healthcare databases in France: A proof‐of‐concept study using the epi‐meres nationwide mother–child register

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Besides registries, healthcare databases can provide useful information for assessing the frequency of major congenital malformations (MCMs) and investigating their risk factors, particularly medication exposures. This study aimed to assess the validity of MCMs identification based on French national, comprehensive healthcare databases ...
Tom Duchemin, Lise Marty, Jérôme Drouin, Sara Miranda, Jérémie Botton, Valérie Olié, Alain Weill, Rosemary Dray‐Spira   +7 more
wiley   +1 more source

Maternal region of birth and stillbirth trends in Victoria, Australia, 2012–2019: a cohort study

BMJ Public Health
Introduction Given the increasing attention to reduce stillbirth rates in migrant women and variable clinical guidance, we quantified contemporary trends in stillbirth based on maternal region of birth.Methods Population-based study of singleton births ...
Miranda Davies-Tuck, Tanya Farrell, Mary-Ann Davey, Natalie Holowko, Natalie Y Liu, Sharon Weerasingha, Roshan Selvaratnam   +6 more
doaj   +1 more source

Improving, But Could Do Better: Trends in Gestation-Specific Stillbirth in Australia, 1994–2015

, 2019
Stillbirth remains a large global problem in low- and middle-income settings but is also a public health concern in high-income countries. Over the past 20 years, stillbirth rates globally have shown little improvement and large disparities.
Georgina M. Chambers, Hilder, Lisa, Chambers, Georgina M, Donnolley, Natasha, Vicki Flenady, Lisa Hilder, Ellwood, David, David Ellwood, Flenady, Vicki, Natasha Donnolley   +9 more
core   +1 more source

Characteristics and temporal trends of EU teratological safety signals and information dissemination to healthcare professionals in the Netherlands—A contribution of the ConcePTION project

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Although regulatory responses to safety signals have been studied, pregnancy‐specific data and their dissemination to medical professionals remain unclear. This study examined the characteristics and temporal trends of teratological safety signals prompting the European Medicines Agency to implement risk minimization measures.
Yrea R. J. van Rijt‐Weetink, Rosanne E. Huisman, Jan‐Peter van Wieringen, H. J. M. J. (Ineke) Crijns, Florence P. A. M. van Hunsel, Anneke L. M. Passier, Sander Borgsteede, A. C. G. (Toine) Egberts, Laura M. Yates, Eugène P. van Puijenbroek   +9 more
wiley   +1 more source

Tetraspanin‐ESCRT sorting drives miR‐29b packaging into extracellular vesicles to reverse fibrosis in intrauterine adhesions

BMEMat, EarlyView.
MiR‐29b is enriched in extracellular vesicles (EVs) via a tetraspanin transporter‐dependent endocytosis and sorting complex required for the endosomal transport (ESCRT)‐dependent pathway. These EVs target the 3′ untranslated region (3′UTR) of TGFB2, thereby inhibiting the TGF‐β/Smad3 signaling pathway and repairing endometrial damage in intrauterine ...
Lihao Chen, Jianfeng Wu, Shunhan Zhang, Siqi Huang, Yingjun Xie, Hongda Chen, Yinghong Yang, Lan Xiao, Ding Wang, Keke Wu, Xiaofang Sun   +10 more
wiley   +1 more source

Stillbirth in twin pregnancies in Stockholm County 2000-2021-A descriptive study.

PLoS ONE
IntroductionThe incidence of stillbirth is higher in twin pregnancies compared with singleton pregnancies. Known risk factors for stillbirth in twin pregnancies include selective fetal growth restriction, twin-to-twin transfusion syndrome (TTTS) and ...
Matilda Varli Hjärne, Cecilia Pegelow Halvorsen, Hanna Åmark   +2 more
doaj   +1 more source

Maternal and foetal medical conditions during pregnancy as determinants of intrapartum stillbirth in public health facilities of Addis Ababa: a case-control study

The Pan African Medical Journal, 2019
INTRODUCTION: Globally, intrapartum stillbirth accounts for 1 million deaths of babies annually, representing approximately one-third of global stillbirth toll.
Alemayehu Gebremariam Agena, Lebitsi Maud Modiba   +1 more
doaj   +1 more source

Humans are not unique: difficult birth is common in placental mammals

Biological Reviews, EarlyView.
ABSTRACT Human childbirth is widely presumed to be uniquely difficult and dangerous compared to birth in other mammals. Tight fetopelvic proportions can result in obstructed labour and contribute to high rates of maternal and neonatal mortality. Ideas summarised under the ‘obstetrical dilemma’ have contributed to this assumption by explaining difficult
Nicole D. S. Grunstra
wiley   +1 more source

Caring for families experiencing stillbirth. Part 1 of 3: diagnosis to birth

, 2014
Joanna Briggs Institute members for the University of Adelaide: Peters M, Riitano D, Lisy K, Jordan Z, Aromataris E. This report is derived from: Peters M, Riitano D, Lisy K, Jordan Z, Aromataris E.
Joanna Briggs Institute,
core