Results 81 to 90 of about 229,022 (309)

Role of dopamine D1-like receptors in methamphetamine locomotor responses of D2 receptor knockout mice [PDF]

, 2008
Behavioral sensitization to psychostimulants manifests as an increased locomotor response with repeated administration. Dopamine systems are accepted to play a fundamental role in sensitization, but the role of specific dopamine receptor subtypes has not
Atkins, Baik, Battisti, Battisti, Boileau, Cador, Chiang, Crabbe, Crawford, de Wit, Down, Fleckenstein, Gabbay, Glickstein, Hamamura, Jones, Kalivas, Kamens, Karler, Karper, Kelly, Kelly, Kilty, Kuczenski, Kuribara, Kuribara, Kuribara, McDougall, Neve, Palmer, Phillips, Phillips, Pierce, Robinson, Ron, Rubinstein, Sax, Schmauss, Shen, Tanabe, Ujike, Vezina, Vezina, Xu, Xu, Xu, Xu, Yates   +47 more
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Cell-Based Radiotracer Binding and Uptake Inhibition Assays: A Comparison of In Vitro Methods to Assess the Potency of Drugs That Target Monoamine Transporters

Frontiers in Pharmacology, 2020
High-affinity monoamine transporters are targets for prescribed medications and stimulant drugs of abuse. Therefore, assessing monoamine transporter activity for candidate medications and newly-emerging drugs of abuse provides essential information for ...
Marija Ilic, Marija Ilic, Marija Ilic, Marion Holy, Kathrin Jaentsch, Matthias E. Liechti, Gert Lubec, Michael H. Baumann, Harald H. Sitte, Dino Luethi, Dino Luethi   +10 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Suicide and psychiatric disorders associated with amphetamine type stimulant use: a systematic review and meta-analysis

Frontiers in Psychiatry
ObjectiveThis study reviews the literature to determine the prevalence and nature of suicidality and psychiatric comorbidity in individuals with amphetamine-type stimulant (ATS) use to inform targeted interventions.MethodsWe searched the Web of Science ...
Halima Mohammed Adam, Ahmed Hamed Aljadani, Mohamed Abouzed, Benayan Bani Alrasheedy, Muath Abdulaziz Alarfaj   +4 more
doaj   +1 more source

Efeito de giberelina (GA3) e do bioestimulante 'Stimulate' na indução floral e produtividade do maracujazeiro-amarelo em condições de safra normal Effect of gibereline (GA3) and biostimulant 'Stimulate' in floral induction and yield of yellow passion fruit in conditions of normal growing season

Revista Brasileira de Fruticultura, 2006
O objetivo do trabalho foi avaliar os efeitos de GA3, nas concentrações de 100; 200 e 300mg L-1 e do bioestimulante Stimulate®, em doses de 2,08; 4,17 e 6,25mL L-1, em duas aplicações via foliar, acrescidas de espalhante adesivo Silwett® a 0,05% e a ...
Elma Machado Ataíde, Carlos Ruggiero, João Carlos de Oliveira, João Domingos Rodrigues, José Carlos Barbosa   +4 more
doaj   +1 more source

From ABCs to ADHD: the role of schooling in the construction of behaviour disorder and production of disorderly objects [PDF]

, 2008
Discussion of Attention-Deficit/Hyperactivity Disorder (ADHD) in the media, and thus much popular discourse, typically revolves around the possible causes of disruptive behaviour and the “behaviourally disordered” child.
Graham, Linda
core   +2 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Effect of Ethephon on the Formation of Traumatic Resin Ducts in Pinus merkusii Seedlings

Forestist
Pinus merkusii shows great potential as a resin-producing wood in Indonesia, with the global demand for pine resin reaching 1 million tons annually. This study investigated the effect of ethephon on the anatomical properties of P. merkusii, particularly
Yogi Feriawan, Widyanto Dwi Nugroho
doaj   +1 more source

First Aid in Common Injuries and Accidents [PDF]

, 1931
PDF pages ...
Przyluska, Wanda
core