Results 91 to 100 of about 706,846 (235)

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Proanthocyanidins from Ginkgo extract EGb 761® improve bioenergetics and stimulate neurite outgrowth in vitro

Frontiers in Pharmacology
EGb 761® is a proprietary extract from Ginkgo biloba leaves approved as an herbal medication for the treatment of dementia and its related disorders. Preclinical studies highlight antioxidant, ROS scavenging, mitochondria-stabilizing, and neuroplastic ...
Imane Lejri, Imane Lejri, Ina Vukalović, Ina Vukalović, Amandine Grimm, Amandine Grimm, Amandine Grimm, Anne Eckert, Anne Eckert   +8 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Desenvolvimento de mudas de alface a partir de sementes armazenadas e enriquecidas com micronutrientes e reguladores de crescimento

Bioscience Journal, 2009
O sucesso da produção de mudas de hortaliças depende da utilização de sementes de boa qualidade. Geralmente, sementes de espécies hortícolas, por serem muitos pequenas, possuem pequena quantidade de reserva e, por isso, o seu enriquecimento com ...
Kênia Almeida Diniz Albuquerque, Paulo de Albuquerque Silva, João Almir Oliveira, José Luiz Sandes de Carvalho Filho, Frederico José Evangelista Botelho   +4 more
doaj  

PIT - Produzieren im Takt®

, 2022
Zunehmend individuelle Kundenwünsche, schwankende Auftragsmengen und hohe Effizienzanforderungen verursachen besonders bei kleinen und mittleren Unternehmen einen hohen Aufwand.

core  

Comparing Medium-Term Clinical Outcomes following XEN® 45 and XEN® 63 Device Implantation

, 2020
Purpose. To evaluate medium-term clinical outcomes with XEN® 45 or XEN® 63 Gel Stent (Allergan, Dublin, Ireland) for treatment of primary open angle glaucoma (POAG). Materials and Methods.
Nuria Garzón, Fernández García, Aitor, Francisco Poyales, Andrango, Henry, Garzón Jiménez, Nuria, Mercedes García-Alonso, Poyales, Francisco, Aitor Fernández-García, Henry D. Andrango, Zhou, Ying, García Alonso, Mercedes, Ying Zhou   +11 more
core   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Molecular Mechanisms of Lacticaseibacillus rhamnosus, LGG^® Probiotic Function

Microorganisms
To advance probiotic research, a comprehensive understanding of bacterial interactions with human physiology at the molecular and cellular levels is fundamental.
Thomas Leser, Adam Baker
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source