Results 61 to 70 of about 3,130,394 (254)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Estimulação magnética transcraniana em psiquiatria

Debates em Psiquiatria, 2012
Objetivo: O objetivo deste artigo foi retratar a experiência com Estimulação Magnética Transcraniana no Instituto de Psiquiatria do Hospital das Clínicas da Faculdade de Medicina de Medicina USP (HC-FMUSP), e sua aplicação na prática clínica ...
Marco Antonio Marcolin, Hellen Livia Drumond Marra, Caio Abujadi, Carlos Gustavo Sardinha Mansur, Martin Luiz Myczkowski, Philip Leite Ribeiro, Rodrigo Lancelote Alberto, Bianca Boura Bellini   +7 more
doaj   +1 more source

Automatic electrical stimulation of abdominal wall muscles increases tidal volume and cough peak flow in tetraplegia [PDF]

, 2008
<p>Paralysis of the respiratory muscles in people with tetraplegia affects their ability to breathe and contributes to respiratory complications.
Allan, D.B., Fraser, M.H., Gollee, H., Hunt, K.J., McLean, A.N.   +4 more
core  

Derailing individualized ovarian stimulation [PDF]

, 2018
No abstract ...
Anderson, Richard A., Nelson, Scott M.
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Research on the Characteristics of Microscopic Damage to Different Pore Types by Slippery Water Fracturing Fluid in the Chang Member Tight Sandstone Reservoir, Ordos Basin, NW China

Geofluids, 2021
This paper examines the damage caused by slickwater fracturing fluid to the microscopic pore structure of tight sandstone in the Chang 7 member in the Ordos Basin.
Aojiang Qi, Pinshu Qian, Hai Huang, Dazhong Ren, Xiaoyu Gu, Fan Zhang, Xun Yuan   +6 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Differential brain reorganization in chronic cervical spinal cord injury and its relation to motor versus sensory impairments: a preliminary investigation

Scientific Reports
Spinal cord injury (SCI) disrupts the communication between the brain and the rest of the body, triggering widespread spinal and supraspinal changes resulting in a cascade of functional impairments.
Nabila Brihmat, Soha Saleh, Fan Zhang, Janelle Carnahan, Mehmed B. Bayram, Guang H. Yue, Gail F. Forrest   +6 more
doaj   +1 more source

Cerebellum to motor cortex paired associative stimulation induces bidirectional STDP-like plasticity in human motor cortex [PDF]

, 2012
The cerebellum is crucially important for motor control and adaptation. Recent non-invasive brain stimulation studies have indicated the possibility to alter the excitability of the cerebellum and its projections to the contralateral motor cortex, with ...
Lu, Ming-Kuei, Tsai, Chon-Haw, Ziemann, Ulf   +2 more
core   +1 more source