Results 81 to 90 of about 976,434 (249)

pH-Responsive Mesoporous Silica and Carbon Nanoparticles for Drug Delivery

Bioengineering, 2017
The application of nanotechnology to medicine constitutes a major field of research nowadays. In particular, the use of mesoporous silica and carbon nanoparticles has attracted the attention of numerous researchers due to their unique properties ...
Miguel Gisbert-Garzarán, Miguel Manzano, María Vallet-Regí   +2 more
doaj   +1 more source

Easily Processable Temperature-Responsive Infrared-Reflective Polymer Coatings [PDF]

, 2017
A temperature-responsive near-infrared reflective coating was fabricated based on a side-chain liquid crystal siloxane polymer using a simple wired-bar method.
Laurens T. de Haan, Guofu Zhou, Albertus P. H. J. Schenning, Schenning, A.P.H.J.; id_orcid, Weixin Zhang, Stijn Kragt, Schenning, A.P.H.J., Zhang, W., de Haan, L.T., Zhou, G., Kragt, S.   +10 more
core   +2 more sources

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Delivering biomedicines with stimuli‑responsive biomaterials

Communications Materials
Stimuli‑responsive (smart) biomaterials are emerging as versatile platforms for the precision delivery of biotherapeutics. Engineered to sense internal or external cues, these materials undergo reversible physicochemical changes that trigger on‑demand ...
Hemant Singh, Zenab Darban, Aliakbar Ebrahimi, Atif Khurshid Wani, Showkeen Muzamil Bashir, Huseyin Avci, Syed Shahabuddin, Rukshana Mangattu Veettil, Fawzi Banat, Shabir Hassan   +9 more
doaj   +1 more source

Next generation, in-situ microfluidic flow control using stimuli responsive materials for biomemetic microfluicic platforms

, 2016
The requirement of significant off-chip fluid manipulation using high-cost mechanical components has resulted in design limitations in microfluidic devices. We report the use of novel stimuli responsive polymer gel materials for a variety of bio-inspired
Coleman, Simon, Azouz, Aymen Ben, Schenning, Albert, Whyte, Jeffrey, Benito-Lopez, Fernando, Schiphorst, Jeroen Ter, McCluskey, Peter, Kent, Nigel, Diamond, Dermot, Schenning, Albert; id_orcid, Saez, Janire   +10 more
core  

Programmed morphing of liquid crystal networks [PDF]

, 2014
A promising candidate for the development of stimuli-responsive morphing materials are based on liquid crystal polymer networks. These anisotropic materials will contract along the alignment director and expand perpendicular to it when subjected to an ...
Schenning, APHJ Albert, Haan, de, L.T., Broer, D.J., Schenning, A.P.H.J.; id_orcid, Broer, D.J.; id_orcid, Schenning, A.P.H.J., Broer, DJ Dirk=Dick, Haan, LT Laurens de   +7 more
core   +2 more sources

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Light-Responsive Hierarchically Structured Liquid Crystal Polymer Networks for Harnessing Cell Adhesion and Migration [PDF]

, 2017
Extracellular microenvironment is highly dynamic where spatiotemporal regulation of cell-instructive cues such as matrix topography tightly regulates cellular behavior.
Hailu G. Kassa, Koçer, Gülistan, Kassa, H.G., Albertus P. H. J. Schenning, Pascal Jonkheijm, Leclère, P.E.L.G., Philippe Leclère, Schenning, APHJ Albert, Jonkheijm, P Pascal, Schiphorst, J Jeroen ter, Hendrikx, M., Jonkheijm, P., Hendrikx, Matthew, Jeroen ter Schiphorst, Jonkheijm, Pascal, Kassa, Hailu G, Koçer, G., Leclere, PELG Philippe, ter Schiphorst, Jeroen, Schenning, Albertus P.H.J., Schenning, A.P.H.J.; id_orcid, Hendrikx, M Matthew, Kassa, Hailu G., Leclère, Philippe, Schenning, A.P.H.J., Koçer, G, ter Schiphorst, J., Gülistan Koçer, Matthew Hendrikx   +28 more
core   +3 more sources

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source