Results 91 to 100 of about 585,821 (290)

Multi-stimuli responsive nanoparticles: next-generation platforms for smart drug delivery

OpenNano
Stimuli-responsive nanoparticles (NPs) are a major improvement to standard drug delivery methods because these allow the release of therapeutic agents in response to a particular biological response.
Qadeer Ahmad, Shumaila Mehdi, Bushra Shaukat, Rida Siddique, Muhammad Talha Asif, Abdul Malik, Safeer Khan, Ruqaiyyah Siddiqui, Naveed Ahmed Khan, Malik Hassan Mehmood   +9 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

Phospholipid Encapsulated AuNR@Ag/Au Nanosphere SERS Tags with Environmental Stimulus Responsive Signal Property

, 2016
Surface-enhanced Raman scattering (SERS) tags draw much attention due to the ultrasensitivity and multiplex labeling capability. Recently, a new kind of SERS tags was rationally designed by encapsulating metal nano particles with phospholipid bilayers ...
Sun, KX, Wang, YQ, Chen, LX (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China. yqwang@yic.ac.cn, Su, XM, Chen, LX, sunkx@ytu.edu.cn, lxchen@yic.ac.cn, Sun, KX (reprint author), Yantai Univ, Shandong Univ,Sch Pharm, Key Lab Mol Pharmacol & Drug Evaluat,Minist Educ, Collaborat Innovat Ctr Adv Drug Delivery Syst & B, Yantai 264005, Peoples R China., Wang, WH   +8 more
core   +1 more source

Harnessing stimuli‐responsive biomaterials for advanced biomedical applications

Exploration
Cell behavior is intricately intertwined with the in vivo microenvironment and endogenous pathways. The ability to guide cellular behavior toward specific goals can be achieved by external stimuli, notably electricity, light, ultrasound, and magnetism ...
Ziming Liao, Tingting Liu, Zhimin Yao, Tian Hu, Xiaoyuan Ji, Bin Yao   +5 more
doaj   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Stimulus Responsive Nanoparticles

, 2017
Disclosed are various embodiments of methods and systems related to stimulus responsive nanoparticles. In one embodiment including a stimulus responsive nanoparticle system, the system includes a first electrode, a second electrode, and a plurality of ...
Sierros, Konstantinos A., Cairns, Darran Robert, Shafran, Matthew S., Huebsch, Wade W.   +3 more
core   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Stimulus Responsive Nanoparticles

, 2015
Disclosed are various embodiments of methods and systems related to stimulus responsive nanoparticles. In one embodiment includes a stimulus responsive nanoparticle system, the system includes a first electrode, a second electrode, and a plurality of ...
Cairns, Darran Robert, Sierros, Konstantinos A., Shafran, Matthew S., Huebsch, Wade W.   +3 more
core   +1 more source

Stimulus-related priming during task switching

, 2018
Task switch cost (the deficit of performing a new task vs. a repeated task) has been partly attributed to priming of the repeated task, as well as to inappropriate preparation for the switched task.
John R. Anderson (294859), Myeong-Ho Sohn (5359037)   +1 more
core   +1 more source