The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source
So Are We Keynesians or Not? [PDF]
There is plenty of room for empirical debate with respect to the efficacy of fiscal policy in general, whether monetary policy is a better tool, or what constitutes spending that will make us more productive in the future.Martin Kennedy, Keynes ...
Martin Kennedy
core
Stimulus for Greater Philadelphia: What it Means for Transportation Investment in the Region [PDF]
, 2009 Key Takeaways Greater Philadelphia will likely receive more than $600 million from the $48.1 billion in transportation stimulus funds, including approximately $318 for highways in southeastern Pennsylvania, $120 million for highways in southern New ...
core
Human summating potential using continuous loop averaging deconvolution: Response amplitudes vary with tone burst repetition rate and duration [PDF]
, 2017 Electrocochleography (ECochG) to high repetition rate tone bursts may have advantages over ECochG to clicks with standard slow rates. Tone burst stimuli presented at a high repetition rate may enhance summating potential (SP) measurements by reducing ...
Delgado, Rafael E +4 more
core +3 more sources
Integration of circadian and hypoxia signaling via non‐canonical heterodimerization
FEBS Letters, EarlyView.CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley +1 more source
The use of Teddy Bears to help develop interpersonal context to promote intrinsic motivation
Actualidades Investigativas en Educación, 2004 This article is based on the findings of using a teddy bear as a tool to provide a way of increasing pupils ’ motivation toward learning by means of using a stuffed animal such as a teddy bear named Ken Bear and relating it to learning a L2.
Tamatha Rabb Andrews
doaj +1 more source
The State and Local Drag on the Stimulus [PDF]
This report shows that the $787 billion included in the 2009 ARRA will not have as much of an immediate effect on the economy as initially anticipated. After subtracting the annual AMT patch and acounting for state level spending and tax cuts, the full ...
Dean Baker, Rivka Deutsch
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Cholinergic modulation of dopamine overflow in the rat neostriatum: A fast cyclic voltammetric study in vitro [PDF]
, 1994 Stimulus-evoked dopamine overflow in rat neostriatal slices was determined using fast cyclic voltammetry. The dopamine efflux induced by intrastriatal stimulation increased with stimulus intensity and was found to be enhanced by more than 100% upon ...
Kudernatsch, Martina, Sutor, Bernd
core +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source