Results 101 to 110 of about 24,517 (327)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

open access: yesFEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas   +6 more
wiley   +1 more source

Balancing the Scales: Limiting the Prejudicial Effect of Evidence Rule 404(B) through Stipulation

open access: yes, 1994
This Note argues that, in a prosecution for a violation of a specific intent criminal statute, the government must accept a defendant’s clear and unambiguous stipulation to possessing the requisite intent for the crime charged.
Buzzetta, Daniel J.
core   +1 more source

DECISION STIPULATION ON NATIONAL AIR SPACE ZONE OF THE REPUBLIC OF INDONESIA [PDF]

open access: yes, 2019
The designation of airspace areas is very important and strategic for the integrity and sovereignty of a nation state. Also, understanding the airspace area of a country is beneficial to the interests of human beings living in the country's "demarcation ...
Paraga, Sukardi   +4 more
core  

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

open access: yesFEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

open access: yesFEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

АКТУАЛЬНОЕ ЧЛЕНЕНИЕ ХУДОЖЕСТВЕННЫХ ТЕКСТОВ В ЯЗЫКОВОЙ КАРТИНЕ МИРА

open access: yesStudia Rossica Posnaniensia, 2018
The necessity of a multiaspect text analysis is caused by the characteristics of the text as an integral literary work. Actual articulation of textual units supposes taking into consideration the prior stipulation of the author’s choice with the regard ...
Лариса Клокова   +1 more
doaj  

Indonesian Business Competition Law post the enactment Government Regulation in Lieu of Law on Job Creation Regulation into Law

open access: yesJustisi
This study aims to find out the development of business competition law in Indonesia as stipulated in Law Number 5 of 1999 on the Prohibition of Monopolistic Practices and Unfair Business Competition and its impact on the dynamics of business competition
Gusliadi Gusliadi   +3 more
doaj   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

open access: yesFEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson   +6 more
wiley   +1 more source

40 Years after the First Agreement. Assessments, Perspectives, Critical Issues, Rome, Sala della Regina, Montecitorio Palace, 19 February 2025

open access: yesStudia z Prawa Wyznaniowego
This report summarises the proceedings of the conference “40 years after the first agreement. Assessments, perspectives, critical issues”, organised in Rome (Sala della Regina, Montecitorio Palace) on 19 February 2025 by the Federation of Evangelical ...
Davide Dimodugno
doaj   +1 more source

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