Results 131 to 140 of about 24,517 (327)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Gates v. Police Commission 93. Stipulation to entry of judgement; Proposed order, lodged 1991-04-29
, 1991 Exhibit 93: Attorneys for respondents. Superior Court of California County of Los Angeles. Daryl F. Gates, petitioner, vs. Board of Police Commissioners of the City of Los Angeles, municipal board, and the City of Los Angeles, a municipal corporation ...
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Pengecualian terhadap Penerapan Asas Ultra Petitum Partium dalam Beracara di Pengadilan Agama
Mimbar Hukum, 2012 A judge must examine and adjudicate all charges thoroughly on the lawsuit brought to the court. The judge should not only examine and adjudicate part of the charge and disregard the rest.
Mrs. Hartini
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FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
, 2011 In the last few years, due to the process of students\ue2 political socialization and the promotion of campus democracy and feminism awareness, the management of the correct clothing manners discipline stipulation has become an important issue for the ...
Chen, Bu-Chin
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FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Should physical symmetries guide metaphysics? Two reasons why they should maybe not. [PDF]
Eur J Philos Sci, 2023 López C.
europepmc +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Studia Universitatis Moldaviae: Stiinte Sociale, 2007 Death punishment is on of the most discussed subject in the theory of criminal law. There are arguments in favor or against stipulation of the death punishment in criminal codes of different countries, depending of its necessity and contribution to ...
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