Results 161 to 170 of about 24,517 (327)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

The Republican River Dispute: An Analysis of the Parties\u27 Compact Interpretation and Final Settlement Stipulation

open access: yes, 2004
With the arrival of the twentieth century, technology allowed surface water supplies to be used by communities, industry, and agriculture in greater quantities, and be used farther away from the water’s source. In addition, public works undertaken in the
Popelka, Aaron M.
core   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

Gates v. Police Commission 78. Amended stipulation for entry of judgement and permanent injunction; Order, rec'd 1991-04-19

open access: yes, 1991
Exhibit 78: Attorneys for petitioner, Daryl F. Gates. In the Superior Court of the State of California for the County of Los Angeles. Daryl F. Gates, Chief of the Police of the Police Department of the City of Los Angeles, petitioner, vs. Board of Police

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Advancing human ovarian biology in tandem with clinical care: considerations for collecting ovarian tissue for research after oophorectomy for tissue cryopreservation. [PDF]

open access: yesFront Endocrinol (Lausanne)
Brunette MA   +8 more
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Problem of the stipulation of rules and regulations of land management for agricultural land reform

open access: yes
การศึกษาค้นคว้าอิสระ มีวัตถุประสงค์เพื่อศึกษาความเป็นมา แนวคิด และทฤษฎี เกี่ยวกับการปฏิรูปที่ดินเพื่อเกษตรกรรม หลักการออกกฎและปัญหาความชอบด้วยกฎหมายเกี่ยวกับการออกกฎระเบียบการจัดที่ดินในการปฏิรูปที่ดินเพื่อเกษตรกรรม การเปรียบเทียบกฎหมายเกี่ยวกับปฏิรูปท ...
อนุวัช วิชัย
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