Results 41 to 50 of about 72,594 (306)

Control problem for the impulse process under stochastic optimization procedure and Levy conditions

open access: yesМатематичні Студії, 2021
A stochastic approximation procedure and a limit generator of the original problem are constructed for a system of stochastic differential equations with Markov switching and impulse perturbation under Levy approximation conditions with control, which is
Ya. M. Chabanyuk   +2 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

open access: yesFEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

On Probabilistic Convergence Rates of Symmetric Stochastic Bernstein Polynomials

open access: yesMathematics
This paper analyzes the exponential convergence properties of Symmetric Stochastic Bernstein Polynomials (SSBPs), a novel approximation framework that combines the deterministic precision of classical Bernstein polynomials (BPs) with the adaptive node ...
Shenggang Zhang   +2 more
doaj   +1 more source

Stochastic Approximation on Riemannian Manifolds [PDF]

open access: yesApplied Mathematics & Optimization, 2019
The standard theory of stochastic approximation (SA) is extended to the case when the constraint set is a Riemannian manifold. Specifically, the standard ODE method for analyzing SA schemes is extended to iterations constrained to stay on a manifold using a retraction mapping. In addition, for submanifolds of a Euclidean space, a framework is developed
openaire   +3 more sources

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

A STOCHASTIC APPROXIMATION ALGORITHM FOR STOCHASTIC SEMIDEFINITE PROGRAMMING [PDF]

open access: yesProbability in the Engineering and Informational Sciences, 2016
Motivated by applications to multi-antenna wireless networks, we propose a distributed and asynchronous algorithm for stochastic semidefinite programming. This algorithm is a stochastic approximation of a continuous-time matrix exponential scheme which is further regularized by the addition of an entropy-like term to the problem's objective function ...
Gaujal, Bruno, Mertikopoulos, Panayotis
openaire   +5 more sources

On integer stochastic approximation [PDF]

open access: yes, 1984
summary:Let $M : \bold R \rightarrow \bold R$ be observable, with experimental errors, at integer points only; unknown elsewhere. Iterative nonparametric procedures for finding the zero point of $M$ are called procedures of integer stochastic ...
Herkenrath, Ulrich, Dupač, Václav
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

open access: yesAging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang   +3 more
wiley   +1 more source

Approximation algorithms for stochastic clustering

open access: yesJ. Mach. Learn. Res., 2018
We consider stochastic settings for clustering, and develop provably-good approximation algorithms for a number of these notions. These algorithms yield better approximation ratios compared to the usual deterministic clustering setting. Additionally, they offer a number of advantages including clustering which is fairer and has better long-term ...
David G. Harris 0001   +4 more
openaire   +5 more sources

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