Results 41 to 50 of about 25,372,776 (322)

Non-parametric probabilistic seismic capacity model for the stochastic interaction system of soil-subway station structures

Underground Space
A reasonable seismic capacity model is crucial for establishing the seismic performance level system and evaluating the seismic reliability of subway station structures.
Minze Xu, Chunyi Cui, Hailong Liu, Jingbo Li, Jingtong Zhao, Chengshun Xu   +5 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Planning of Cascade Hydropower Stations with the Consideration of Long-Term Operations under Uncertainties

Complexity, 2019
In the location-related planning of a hydropower system, the consideration of future operations under uncertainties can make the decisions sustainable and robust.
Changjun Wang, Shutong Chen
doaj   +1 more source

Detecting change in stochastic sound sequences.

PLoS Computational Biology, 2018
Our ability to parse our acoustic environment relies on the brain's capacity to extract statistical regularities from surrounding sounds. Previous work in regularity extraction has predominantly focused on the brain's sensitivity to predictable patterns ...
Benjamin Skerritt-Davis, Mounya Elhilali
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Ultimate a seismic capacity of high earth-rock dams based on stochastic dynamic analysis

Yantu gongcheng xuebao
The randomness of seismic motion significantly affects the dynamic response of dams. The ultimate capacity is a critical factor for the seismic safety of dams, thus during the assessment process the influences of load randomness should be thoroughly ...
PANG Rui 1, 2, , LU Yunzhu 1, JI Rui 1, XU Bin 1, 2
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

System Capacity Analysis for Ultra-Dense Multi-Tier Future Cellular Networks

IEEE Access, 2019
Ultra-dense multi-tier cellular networks have recently drawn the attention of researchers due to their potential efficiency in dealing with high-data rate demands in upcoming 5G cellular networks.
Syed Waqas Haider Shah, Adnan Noor Mian, Shahid Mumtaz, J. Crowcroft   +3 more
semanticscholar   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Development of Innovative Healthcare Management through Institutional and Financial Capacity Adaptation [PDF]

Marketing i Menedžment Innovacij
The evaluation of healthcare system effectiveness constitutes an integral component of healthcare management, yet existing assessment practices differ substantially in their capacity to support management-oriented interpretation and system adaptation ...
doaj   +1 more source