Results 251 to 260 of about 221,775 (313)

Revisiting Target‐Aware de novo Molecular Generation with TarPass: Between Rational Design and Texas Sharpshooter

open access: yesAdvanced Science, EarlyView.
TarPass provides a rigorous benchmark for target‐aware de novo molecular generation by jointly evaluating protein‐ligand interactions, molecular plausibility, and drug‐likeness on 18 well‐studied targets. Results show that current models often fail to consistently surpass random baseline in target‐specific enrichment, while post hoc multi‐tier virtual ...
Rui Qin   +11 more
wiley   +1 more source

Topology‐Enriched Toughness Enhancement in Quasi‐Periodic Metastructures Featuring Tailorable Strong‐Weak Network

open access: yesAdvanced Science, EarlyView.
A quasi‐periodic Dart‐Kite (QDK) metastructure with a golden‐ratio‐constrained strong–weak bond network simultaneously enhances strength, toughness, and damage tolerance. Its distributed topology enables predictable, tailorable crack paths for precise fracture control and stable mechanics, demonstrating a high‐performance, controllable architecture ...
Tianyu Gao   +3 more
wiley   +1 more source

Bias and Its Control in Stochastic Approaches to Electronic-Structure Theory. [PDF]

open access: yesJ Chem Theory Comput
Savchenko P   +4 more
europepmc   +1 more source

A control theoretical approach to gene regulation reveals quantitative constraints for dynamic homeostasis in stochastic gene expression. [PDF]

open access: yesBiochim Biophys Acta Mol Basis Dis
Giovanini G   +5 more
europepmc   +1 more source

Controlling Stochastic Resonance

Physical Review Letters, 1999
Stochastic resonance (SR) is a nonlinear noise-mediated cooperative phenomenon wherein the coherent response to a deterministic signal can be enhanced in the presence of an optimal amount of noise. Since its inception in 1981 [1], SR [2] has been demonstrated in diverse systems including sensory neurons, mammalian neuronal tissue, lasers, SQUIDs ...
GAMMAITONI, Luca   +7 more
openaire   +2 more sources

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