Results 181 to 190 of about 14,387 (264)

RUNX2 Activation in Fibro/Adipogenic Progenitors Promotes Muscle Fibrosis in Muscular Dystrophy

Advanced Science, EarlyView.
This study revealed a novel role of the chemokine‐TGF‐β1‐RUNX2 axis in determining the fate of FAP differentiation and modulating muscle fibrosis in patients and mice with muscular dystrophies. ABSTRACT Clinical evidence indicates concurrent muscle inflammation and fibrosis in muscular dystrophies (MDs); however, the molecular mechanisms underlying ...
Pengkai Wu, Zehua Zhang, Kai Zheng, Ziqi Zhu, Yong Zhu, Abdukahar Kiram, Lei Zhao, Huihui Chen, Zhu Xu, Xihua Li, Beicheng Sun, Zhijian Li, Dengqiu Xu   +12 more
wiley   +1 more source

Earthquake frequency-magnitude distribution at Mount Etna sheds light on magma ascent in the volcano's plumbing system. [PDF]

Sci Adv
Firetto Carlino M, Lo Bue R, Taroni M, Coltelli M, Cannavò F, Cocina O, Barberi G, Scarfì L.   +7 more
europepmc   +1 more source

Inhibition of SLC11A1‐Mediated Lysosomal Iron Accumulation in Microglia Promotes Repair Following White Matter Stroke

Advanced Science, EarlyView.
Genetic and pharmacological inhibition of SLC11A1 functioning as an H+/Fe2+ antiporter–mediated lysosomal iron accumulation in microglia promotes lysosomal lumen acidification, increases CTSD expression, enhances lysosomal myelin debris uptake and degradation, and promotes repair following white matter stroke. ABSTRACT White matter stroke (WMS) results
Lingling Qiu, Yajie Zhang, Yushi Tang, Hongli Hu, Ying Zhang, Junwen Xue, Hao Wang, Yecheng Wang, Chunfeng Liu, Jia Jia, Jian Cheng, Yongjun Cao   +11 more
wiley   +1 more source

Retardance and depolarization of brain white matter as markers for intraoperative delineation of brain tumors: experiments and simulations. [PDF]

Biomed Opt Express
Wang M, Chae S, Lukinsone V, Lucas T, Rodríguez-Nuñez O, Gros É, Hahne C, Maragkou T, McKinley R, Schucht P, Novikova T.   +10 more
europepmc   +1 more source

Precision Editing of NLRS Improves Effector Recognition for Enhanced Disease Resistance

Advanced Science, EarlyView.
Precision engineering of plant NLR immune receptors enables rational design of enhanced pathogen resistance through mismatched pairing, domain swapping, and targeted mutagenesis. These approaches achieve multi‐fold expansion in recognition breadth while minimizing autoimmunity risks and fitness penalties.
Vinit Kumar, Vishwa I. P. W. A. Kumara, Pradeepa C. G. Bandaranayake, Dong Yawen, Yang‐Yang Gao, Junfeng Liu, Ge‐Fei Hao, Xiu‐Fang Xin   +7 more
wiley   +1 more source

Integrative Analysis of Metabolome and Proteome in the Cerebrospinal Fluid of Patients with Multiple System Atrophy. [PDF]

Cells
George NP, Kwon M, Jang YE, Kim SG, Hwang JS, Lee SS, Lee G.   +6 more
europepmc   +1 more source

A Virtual Clinical Trial of Psychedelics to Treat Patients With Disorders of Consciousness

Advanced Science, EarlyView.
Disorders of consciousness after severe brain injury are marked by reduced complexity of brain activity and limited treatment options. Using personalized whole‐brain models, this study shows that simulated lysergic acid diethylamide (LSD) and psilocybin shift patient brain dynamics closer to criticality.
Naji L.N. Alnagger, Paolo Cardone, Charlotte Martial, Yonatan Sanz Perl, Iván Mindlin, Jacobo D Sitt, Leor Roseman, Robin Carhart‐Harris, David Nutt, Pablo Mallaroni, Natasha Mason, Johannes G Ramaekers, Vincent Bonhomme, Steven Laureys, Gustavo Deco, Olivia Gosseries, Pablo Núñez, Jitka Annen   +17 more
wiley   +1 more source

Exploration of Epigenetic Mechanisms and Biomarkers Among Patients with Very-Late-Onset Schizophrenia-Like Psychosis. [PDF]

Neuropsychiatr Dis Treat
Gan Y, Yue W, Sun J, Yang D, Fang C, Zhou Z, Yin J, Zhou H.   +7 more
europepmc   +1 more source

Quasi‐Periodic Porous Structures‐Based Temperature and Pressure Dual‐Mode Electronic Skin for Material Cognition

Advanced Science, EarlyView.
A quasi‐periodic porous structure‐based temperature and pressure dual‐mode electronic skin was proposed. Benefiting from the quasi‐periodic porous structure, the temperature and pressure sensing performance of the electronic skin can be precisely constructed and optimized by changing the size of the porous structure. By analyzing the thermoelectric and
Xiaoguang Gao, Chengzhen Xue, Xiaoliang Zhang, Xuejuan Meng, Xiaochun Li, Li Niu   +5 more
wiley   +1 more source

Modeling and analysis of filtration processes in oil reservoirs of small fields by reserves. [PDF]

Sci Rep
Alisheva Z, Al-Dujaili AN, Tileuberdi N, Muratova S, Omirzakova E, Sanatbekov M, Kurmanbayev O, Alzhigitova M.   +7 more
europepmc   +1 more source