Results 231 to 240 of about 15,207 (302)

Model‐Enabled Knowledge Transfer Across Cell Lines, Culture Scales and Conditions

open access: yesBiotechnology and Bioengineering, EarlyView.
ABSTRACT Mechanistic models are central to quantitative understanding and optimization of Chinese hamster ovary (CHO) cell culture processes, but their utility is often restricted by parameter sets calibrated for specific cell lines, scales, or operating conditions.
Luxi Yu   +2 more
wiley   +1 more source

LLM‐Guided Parameter Optimization for Mechanistic CHO Cell Bioreactor Models

open access: yesBiotechnology and Bioengineering, EarlyView.
ABSTRACT Mechanistic models of Chinese Hamster Ovary (CHO) cell cultures are essential for efficient bioprocess development and control, yet parameter estimation remains a critical challenge in model calibration. As model complexity increases, the number of parameters grows and their values become highly system‐specific due to biological variability ...
Han Bit Kim   +4 more
wiley   +1 more source

Evidence for adaptive explanations of semelparity in animals

open access: yesBiological Reviews, EarlyView.
ABSTRACT Semelparity, the reproductive strategy of reproducing once, is widespread but uncommon in animals. Classes of models to explain the evolution of semelparity are based either on age structure and mortality schedules – demographic models in which high post‐reproductive mortality risk favours high reproductive effort and semelparity results from ...
Diana O. Fisher   +1 more
wiley   +1 more source

Coclique level structure for stochastic chemical reaction networks. [PDF]

open access: yesJ Math Biol
Bruno S   +4 more
europepmc   +1 more source

Stochastic finite elements vs Monte Carlo simulations

open access: yes, 1998
Olsson, Anders, Sandberg, Göran
core  

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