Results 51 to 60 of about 104,993 (265)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

The Stochastic Nature of the Mining Production Process—Modeling of Processes in Deep Hard Coal Mines

Energies
The stochastic and undetermined nature of longwall coal mining results from the complex interaction between geological-mining and technical-organizational factors. This interaction causes variability in key parameters of the production process.
Ryszard Snopkowski, Marta Sukiennik, Aneta Napieraj   +2 more
doaj   +1 more source

Multi-Objective Demand Response Model Considering the Probabilistic Characteristic of Price Elastic Load

Energies, 2016
Demand response (DR) programs provide an effective approach for dealing with the challenge of wind power output fluctuations. Given that uncertain DR, such as price elastic load (PEL), plays an important role, the uncertainty of demand response behavior ...
Shengchun Yang, Dan Zeng, Hongfa Ding, Jianguo Yao, Ke Wang, Yaping Li   +5 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Physically Unclonable Function Utilizing Stochastic Indirect Exchange Interaction

Small Structures
In hardware‐based security, physically unclonable function (PUF) has emerged as a promising solution for generating secret keys. While complementary metal–oxide–semiconductor‐based PUFs have been extensively studied, their reliability and scalability ...
Jeong Kyu Lee, Ye Eun Kim, Min Hyeok Lee, Young Keun Kim   +3 more
doaj   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Stochastic solution framework for the resonance nonlinear Schrödinger model via Brownian motion process [PDF]

AIP Advances
Despite substantial research into nonlinear Schrödinger equation equations, present techniques frequently tackle resonant nonlinear dynamics and stochastic perturbations separately, limiting comprehension of their combined impact on wave propagation.
H. S. Alayachi
doaj   +1 more source

Species associations in a species-rich subtropical forest were not well-explained by stochastic geometry of biodiversity. [PDF]

PLoS ONE, 2014
The stochastic dilution hypothesis has been proposed to explain species coexistence in species-rich communities. The relative importance of the stochastic dilution effects with respect to other effects such as competition and habitat filtering required ...
Qinggang Wang, Dachuan Bao, Yili Guo, Junmeng Lu, Zhijun Lu, Yaozhan Xu, Kuihan Zhang, Haibo Liu, Hongjie Meng, Mingxi Jiang, Xiujuan Qiao, Handong Huang   +11 more
doaj   +1 more source

Stochastic Closures for Wave–Current Interaction Dynamics [PDF]

Journal of Nonlinear Science, 2019
Version accepted at J NonLin Sci, comments still ...
openaire   +3 more sources

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source