Results 141 to 150 of about 85,002 (312)

TRMT6‐Mediated m1A Modification of CDK9 mRNA Is a Dual‐Pronged Pathogenic Driver for HBV‐Related Hepatocellular Carcinoma

Advanced Science, EarlyView.
TRMT6‐mediated m1A modification in CDK9 mRNA enhances its mRNA stability and translation efficiency, thereby increasing the protein levels of CDK9. Upregulated CDK9 promotes the progression of HCC by elevating the levels of oncogenic factors including p‐STAT3, MCL1, and BCL‐2. On the other hand, CDK9 phosphorylates TARDBP at Ser254 to activate HBV core
Rui Zhang, Dandan Zong, Rui Liu, Yubo Wang, Qingqing Gu, Yao Yao, Wenfang Zheng, Mengmeng Yuan, Simeng Wang, Rongrong Cui, Daxu Li, Siwen Dang, Peng Hou   +12 more
wiley   +1 more source

Almost sure exponential stabilisation of stochastic systems by state-feedback control

, 2008
So far, a major part of the literature on the stabilisation issues of stochastic systems has been dedicated to mean square stability. This paper develops a new class of criteria for designing a controller to stabilise a stochastic system almost surely ...
Hu, L., Mao, X., Mao, Xuerong, Hu, Liangjian   +3 more
core   +1 more source

Modeling nonlinear stochastic kinetic system and stochastic optimal control of microbial bioconversion process in batch culture

Nonlinear Analysis, 2013
In this paper, we analyze a stochastic model representing batch fermentation in the process of glycerol bio-dissimilation to 1,3-propanediol by klebsiella pneumoniae.
Lei Wang, Enmin Feng, Zhilong Xiu
doaj  

Perspective: Hollow Core Optical Fibres for Ultraviolet and Visible Wavelengths

Advanced Science, EarlyView.
Hollow core optical fibres bypass material constraints that limit optical fibres at ultraviolet and visible wavelengths. However, their challenging fabrication has limited their development, and significant gains in performance remain possible. In this perspective we outline approaches to enable the next generation of fibres for shorter wavelengths ...
Robbie Mears, Kerrianne Harrington, Jonathan C. Knight, William J. Wadsworth, James M. Stone, Tim A. Birks   +5 more
wiley   +1 more source

Degradation Tolerant Optimal Control Design for Stochastic Linear Systems

International Journal of Applied Mathematics and Computer Science
Safety-critical and mission-critical systems are often sensitive to functional degradation at the system or component level. Such degradation dynamics are often dependent on system usage (or control input), and may lead to significant losses and a ...
Kanso Soha, Jha Mayank Shekhar, Theilliol Didier   +2 more
doaj   +1 more source

eQTL Meta‐Analysis Reveals Conserved and Population‐Specific Regulatory Variation Underlying Nutritional Trait Evolution and Domestication in Tomato

Advanced Science, EarlyView.
A comprehensive meta‐analysis of expression quantitative trait loci (eQTLs) across five diverse tomato populations reveals a high‐resolution atlas of transcriptional regulation and uncovers conserved and population‐specific regulatory architectures underlying fruit nutritional quality traits, including flavonoids, sugars, organic acids, carotenoids ...
Jiantao Zhao, Xin Wang, Jing Zhang, Ryan McQuinn, Je Min Lee, Itay Gonda, Ari Feder, Yimin Xu, Baike Wang, Qinghui Yu, Denise M. Tieman, Sanwen Huang, Harry Klee, James J. Giovannoni, Zhangjun Fei   +14 more
wiley   +1 more source

Optimal control prevents itself from eradicating stochastic disease epidemics.

PLoS Computational Biology
The resources available for managing disease epidemics - whether in animals, plants or humans - are limited by a range of practical and financial constraints.
Rachel Russell, Nik J Cunniffe
doaj   +1 more source

Learning Environmental Field Exploration with Computationally Constrained Underwater Robots: Gaussian Processes Meet Stochastic Optimal Control. [PDF]

Sensors (Basel), 2019
Duecker DA, Geist AR, Kreuzer E, Solowjow E.   +3 more
europepmc   +1 more source

Icariin Enhances the Enzymatic Activity of N‐acetylgalactosaminidase to Augment Akkermansia Abundance in Gut Microbiota for Improved PD‐1 Blockade Efficacy in Tumor Suppression

Advanced Science, EarlyView.
Icariin promoted the growth of Akk by enhancing the activity of N‐acetylgalactosaminidase (Amuc_0920), which enhanced mucin utilization and provided a favorable nutrient environment for bacterial growth. This icariin‐mediated enrichment of Akk further reshaped the tumor microenvironment and promoted CD8+ T cell infiltration, ultimately synergizing with
Shuangying Qiao, Liu Yang, Haibang Hao, Qiuxia Ding, Feng Ding, Zheng Chen, Jinfang Zhang, Yun He, Meng Li, Jun Xu, Chao Wang, Aiping Lu, Fangfei Li   +12 more
wiley   +1 more source