Results 201 to 210 of about 66,510 (262)

AI‐Assisted Digital Single‐Molecule Activity Tracker for Decoupling Intrinsic Heterogeneity from Photo‐Oxidative Damage in High‐Photon‐Flux Enzymology

Advanced Science, EarlyView.
Employing a digital single‐molecule activity tracker (dSMAT), this research demonstrates that high‐photon‐flux irradiation drives progressive oxidative scarring in polymerases. Unlike simple thermal denaturation, real‐time kinetic tracking dynamically visualizes enzymes degrading into multiple impaired subpopulations.
Anran Zheng, Qi Yang, Jinze Li, Fuqiang Ma, Xuefeng Wang, Zhen Guo, Chuanyu Li, Dongshu Li, Jia Yao, Zhiqi Zhang, Wei Zhang, Lianqun Zhou   +11 more
wiley   +1 more source

Soft actor-critic energy management in three-phase unbalanced microgrids with lagrangian penalty constraints. [PDF]

Sci Rep
Cortés P, Tabares A, Bolaños R, Bonilla K.   +3 more
europepmc   +1 more source

An Integrative Strategy Delineates Modular Metabolic Remodeling and Potential Therapeutic Targets Across Metabolic Diseases

Advanced Science, EarlyView.
An integrative single‐cell atlas across multiple metabolic diseases reveals coordinated metabolic modules and disease‐shared versus disease‐specific pathway activities. By systematically comparing scoring strategies, a robust RankAve framework is established. Coupled with network analysis and drug‐target prediction, this resource uncovers cross‐disease
Kuan Yang, Congxue Hu, Hang Zhao, Xiao Peng, Yiming Yan, Jiasi Wang, Wenqi Jiang, Depeng Mu, Yan Cao, Xia Li, Yunpeng Zhang   +10 more
wiley   +1 more source

Research on railway emergency resource scheduling strategy under multiple uncertainty coupling. [PDF]

PLoS One
Sun J, Wan Y, Lu G, Tang Z.
europepmc   +1 more source

eEF1G Orchestrates Translation to Ensure Meiotic Progression in Transcriptionally Quiescent Spermatocytes

Advanced Science, EarlyView.
eEF1G supports translation elongation of meiotic mRNAs in transcriptionally quiescent leptotene and zygotene spermatocytes. Its depletion in germ cells causes meiotic arrest at the zygotene stage, with defective homologous synapsis and unstable recombination intermediates.
Jianze Xu, Yuwei Hu, Xukun Lu, Yuling Cai, Tongtong Li, Ming Gao, Jinlong Ma, Yuan Gao, Shangming Liu, Zi‐Jiang Chen, Jing Meng, Hongbin Liu, Xiaohua Jiang   +12 more
wiley   +1 more source

Reinforcement learning-based control co-design of digital twin-enabled full-vehicle active suspension systems. [PDF]

Struct Multidiscipl Optim
Tsai YK, Chen YP, Karkaria V, Chen W.
europepmc   +1 more source

Exact Discrete Stochastic Simulation With Deep‐Learning‐Scale Gradient Optimization

Advanced Science, EarlyView.
A 203,796‐parameter gene regulatory network classifies handwritten digits with 98.4% accuracy using exact stochastic dynamics. The framework decouples forward simulation from backward differentiation, making continuous‐time Markov chain models compatible with deep‐learning optimization.
Jose M. G. Vilar, Leonor Saiz
wiley   +1 more source

A stochastic framework to assess the optimal allocation of limited vaccine doses in foot-and-mouth disease outbreaks using game theory. [PDF]

Front Vet Sci
Moreno-Torres KI, Sanderson MW, Rigney C, Schoenbaum M, Delgado A, Arzt J, Heier Stamm JL.   +6 more
europepmc   +1 more source

Optimized scheduling of integrated energy systems: a multi-dimensional electricity, hydrogen, ammonia, heat synergy approach using the LSDBO-WOA algorithm. [PDF]

Sci Rep
Tu N, Yang J, Yan X, Fan Z.
europepmc   +1 more source

Optimizing XGBoost via mSMA_plus: A Novel Meta-Heuristic Approach for High-Precision Multiclass Dry Bean Classification. [PDF]

Biomimetics (Basel)
Subaşi N.
europepmc   +1 more source