Results 121 to 130 of about 12,022 (264)

Stochastic Nanoscale Biophysical Cues as a Basis for the Induction of Glioblastoma‐Like Transcriptional Programs in Astrocytes

Advanced Science, EarlyView.
Stochastic nanoscale physical cues induce glioblastoma (GBM)‐associated transcriptional traits in naïve astrocytes leading to spontaneous formation of spheroids. Cells within spheroids express activated‐MMP2 and a differential gene expression pattern involving P53 and NOTCH3, providing evidence for a role for changes in brain topography, as observed in
Laurent Starck, Tobias Butelmann, Sabrina Hogan, Melika Sarem, Bernd Heimrich, Ritwick Sawarkar, Marie‐Françoise Ritz, Gregor Hutter, V. Prasad Shastri   +8 more
wiley   +1 more source

Alkyltriphenylphosphonium Binding to Cardiolipin Triggers Oncosis in Cancer Cells

Advanced Science, EarlyView.
Alkyltriphenylphosphonium, exemplified by TPP+‐C14, preferentially accumulates in mitochondria and selectively binds to cardiolipin, a key phospholipid of the inner mitochondrial membrane, causing loss of mitochondrial membrane potential, severe cellular ATP depletion, and calcium imbalance.
Jin Li, Hang Zheng, Yuxing Lin, Ziwei Zhao, Yijia Mai, Zhangrong Lou, Qiang Liu, Zhao Ma, Chengjun Wu   +8 more
wiley   +1 more source

Divergent Responses of Bacterial Communities to Permafrost Degradation and Their Associations With Carbon Across Vertical Profiles

Advanced Science, EarlyView.
Bacterial α‐diversity decreases, but stochasticity and community stability increase across the 15 m‐depth vertical profiles and along the degraded gradient within the active layer. The abundance and interaction of core taxa mainly control community stability in the active and permafrost layers, respectively.
Shengyun Chen, Yuzheng Gu, Ali Bahadur, Enyan Liu, Tonghua Wu, Xiaofan Zhu, Yuanqiang Zou, Hewei Liang, Peijie Wei, Linwei Wu, Qingbai Wu, Peizhi Yang, Hongyan Yu, Yunfeng Yang   +13 more
wiley   +1 more source

Promoting Treg Polarization‐Mediated Anti‐Scar and Appendage Regeneration in Wound Healing

Advanced Science, EarlyView.
This study develops a PLGA@LA‐BMP4‐PG bilayer scaffold to address scar formation and appendage loss in skin repair. The piezoelectric PLA layer enhances cell migration via electric fields, while GelMA delivers LA promoting Tregs polarization and BMP4 inhibiting FBs differentiation.
Yiwen Yang, Mingjie Kuang, Jiacheng Shi, Ruiyan Li, Yuhan Zhang, Xinting Liu, Runtan Li, Yong Kang, Bin Yao, Shuquan Zhang, Xiaoyuan Ji   +10 more
wiley   +1 more source

Cellular Snowballing: Cell Adhesion and Migration Drive the Self‐Assembly of Cell‐Microgel Biohybrid Spheroids

Advanced Science, EarlyView.
A new class of biohybrid spheroids is engineered through the self‐assembly of adherent cells and extracellular matrix‐mimetic hydrogel microparticles (microgels). By mimicking a snowballing effect, this approach enables scalable formation of porous, millimeter‐scale spheroids with enhanced cell viability and molecular diffusion.
Zaman Ataie, Sina Kheirabadi, Changhao Li, Aneesh Risbud, Aswathy Sebastian, Istvan Albert, Sulin Zhang, Amir Sheikhi   +7 more
wiley   +1 more source

Cutoff estimation and construction of their confidence intervals for continuous biomarkers under ternary umbrella and tree stochastic ordering settings. [PDF]

Stat Med
Brewer BC, Bantis LE.
europepmc   +1 more source

Inhibition of SLC11A1‐Mediated Lysosomal Iron Accumulation in Microglia Promotes Repair Following White Matter Stroke

Advanced Science, EarlyView.
Genetic and pharmacological inhibition of SLC11A1 functioning as an H+/Fe2+ antiporter–mediated lysosomal iron accumulation in microglia promotes lysosomal lumen acidification, increases CTSD expression, enhances lysosomal myelin debris uptake and degradation, and promotes repair following white matter stroke. ABSTRACT White matter stroke (WMS) results
Lingling Qiu, Yajie Zhang, Yushi Tang, Hongli Hu, Ying Zhang, Junwen Xue, Hao Wang, Yecheng Wang, Chunfeng Liu, Jia Jia, Jian Cheng, Yongjun Cao   +11 more
wiley   +1 more source

Heuristically Adaptive Diffusion‐Model Evolutionary Strategy

Advanced Science, EarlyView.
Building on the mathematical equivalence between diffusion models and evolutionary algorithms, researchers demonstrate unprecedented control over evolutionary optimization through conditional diffusion. By training diffusion models to associate parameters with specific traits, they can guide evolution toward solutions exhibiting desired behaviors ...
Benedikt Hartl, Yanbo Zhang, Hananel Hazan, Michael Levin   +3 more
wiley   +1 more source

Consensus Formation and Change are Enhanced by Neutrality

Advanced Science, EarlyView.
Neutral agents are shown to enhance both the formation and overturning of consensus in collective decision‐making. A general mathematical model and experiments with locusts and humans reveal that neutrality enables robust consensus via simple interactions and accelerates consensus change by reducing effective population size.
Andrei Sontag, Janina A. Hoffmann, Tim Rogers, Christian A. Yates   +3 more
wiley   +1 more source

Hierarchical Summary Statistics Encoding Across Primary Visual and Posterior Parietal Cortices

Advanced Science, EarlyView.
This study shows that mouse V1 simultaneously encodes the ensemble mean and variance of motion, providing a robust summary‐statistic representation that persists despite single‐neuron variability. These signals propagate to PPC, where they are transformed into abstract category representations during decision making.
Young‐Beom Lee, Oliver James, Gaeun Jung, Doyun Lee, Yee‐Joon Kim   +4 more
wiley   +1 more source