Results 181 to 190 of about 1,268,116 (331)

Cellular Heterogeneity in Drug Uptake Amplifies Pharmacodynamic Variability: A Stochastic PK-PD Analysis. [PDF]

CPT Pharmacometrics Syst Pharmacol
Duong NH, Do TN, Nguyen TT, Phan KQ, Nguyen LT.   +4 more
europepmc   +1 more source

Supermodular Stochastic Orders and Positive Dependence of Random Vectors

The supermodular and the symmetric supermodular stochastic orders have been cursorily studied in previous literature. In this paper we study these orders more thoroughly. First we obtain some basic properties of these orders.
Shaked, Moshe, Shanthikumar, J. George
core  

TRMT6‐Mediated m1A Modification of CDK9 mRNA Is a Dual‐Pronged Pathogenic Driver for HBV‐Related Hepatocellular Carcinoma

Advanced Science, EarlyView.
TRMT6‐mediated m1A modification in CDK9 mRNA enhances its mRNA stability and translation efficiency, thereby increasing the protein levels of CDK9. Upregulated CDK9 promotes the progression of HCC by elevating the levels of oncogenic factors including p‐STAT3, MCL1, and BCL‐2. On the other hand, CDK9 phosphorylates TARDBP at Ser254 to activate HBV core
Rui Zhang, Dandan Zong, Rui Liu, Yubo Wang, Qingqing Gu, Yao Yao, Wenfang Zheng, Mengmeng Yuan, Simeng Wang, Rongrong Cui, Daxu Li, Siwen Dang, Peng Hou   +12 more
wiley   +1 more source

Combinatorial Probabilities of Multiple Fragmentation Events Explain Polypeptide MS/MS Intensity Distribution, Overrepresentation of Smaller Fragments, and Missing Middle of Top-Down MS. [PDF]

Rapid Commun Mass Spectrom
Yang W, Alam N, Agar JN.
europepmc   +1 more source

Some stochastic orders of Kotz-type distributions

An identity found by Müller (Ann. Inst. Statist. Math. 53 (2001) 567) for normal distributions is generalized to Kotz-type distributions. Some stochastic orders of Kotz-type distributions are discussed by means of this identity.Stochastic order Kotz-type
Ding, Ying, Zhang, Xinsheng
core  

Perspective: Hollow Core Optical Fibres for Ultraviolet and Visible Wavelengths

Advanced Science, EarlyView.
Hollow core optical fibres bypass material constraints that limit optical fibres at ultraviolet and visible wavelengths. However, their challenging fabrication has limited their development, and significant gains in performance remain possible. In this perspective we outline approaches to enable the next generation of fibres for shorter wavelengths ...
Robbie Mears, Kerrianne Harrington, Jonathan C. Knight, William J. Wadsworth, James M. Stone, Tim A. Birks   +5 more
wiley   +1 more source

Simple picture of how output from ChatGPT-like AI shifts from good to bad. [PDF]

PNAS Nexus
Johnson NF, Huo FY.
europepmc   +1 more source

Integration of Spatiotemporal Multi‐Omics in Peach Fruit Unravels a Metabolic Niche and the Genetic Basis of Trichome‐Mediated Stress Adaptation

Advanced Science, EarlyView.
This study constructed the first spatiotemporal multi‐omics map of peach fruit and discovered a key candidate gene that synergistically regulates trichome development and drought tolerance through the jasmonic acid signaling pathway, providing insights into the coupling mechanism between development and stress resistance.
Zhixin Liu, Ke Cao, Liping Guan, Aizhi Qin, Yong Li, Zihao Zhao, Yinpeng Zhang, Yaping Zhou, Lirong Wang, Xuwu Sun   +9 more
wiley   +1 more source

A hybrid framework for compartmental models enabling simulation-based inference. [PDF]

J Math Biol
Germano DPJ, Zarebski AE, Hautphenne S, Moss R, Flegg JA, Flegg MB.   +5 more
europepmc   +1 more source

Construction of two new general classes of bivariate distributions based on stochastic orders

Journal of Multivariate Analysis, 2015
Hyunju Lee, J. Cha
semanticscholar   +1 more source