Results 171 to 180 of about 661,238 (311)

Ultralow‐Dimensionality Reduction for Identifying Critical Transitions by Spatial‐Temporal PCA

open access: yesAdvanced Science, EarlyView.
The proposed spatial‐temporal principal component analysis (stPCA) method analytically reduces high‐dimensional time‐series data to a single latent variable by transforming spatial information into temporal dynamics. By preserving the temporal properties of the original data, stPCA effectively identifies critical transitions and tipping points.
Pei Chen   +6 more
wiley   +1 more source

Microbiota‐Derived Inosine Suppresses Systemic Autoimmunity via Restriction of B Cell Differentiation and Migration

open access: yesAdvanced Science, EarlyView.
Lactobacillus johnsonii and its associated purine metabolite inosine not only restrict systemic B cell differentiation, but also contribute to immune cell infiltration in the kidneys, thereby serving dual functions in mitigating the progression of systemic lupus erythematosus (SLE).
Lingyu Gao   +15 more
wiley   +1 more source

Nonlinear Harmonics: A Gateway to Enhanced Image Contrast and Material Discrimination

open access: yesAdvanced Science, Volume 12, Issue 11, March 20, 2025.
An unsupervised AFM image contrast enhancement (AFM‐ICE) technique based on the integration of image fusion and histogram equalization, employing wavelet‐based analysis of nonlinear cantilever responses, enables improved visualization of complex multilayer structures with distinct defects, nanoparticles, and heterogeneities, all without additional ...
Pardis Biglarbeigi   +3 more
wiley   +1 more source

GNE‐317 Reverses MSN‐Mediated Proneural‐to‐Mesenchymal Transition and Suppresses Chemoradiotherapy Resistance in Glioblastoma via PI3K/mTOR

open access: yesAdvanced Science, Volume 12, Issue 12, March 27, 2025.
The study identifies MSN as a key regulator of proneural‐to‐mesenchymal transition (PMT) in GSCs, driving resistance to radiotherapy (RT) and temozolomide (TMZ) in glioblastoma (GBM). However, GNE‐317 specifically inhibits MSN, reverses PMT, resensitizes cells to therapy, and shows promise as a targeted strategy to overcome chemoradiotherapy resistance
Yong‐Chang Yang   +15 more
wiley   +1 more source

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