Results 81 to 90 of about 60,348 (227)

Analyzing the Behavior of Neuronal Pathways in Alzheimer's Disease Using Petri Net Modeling Approach

Frontiers in Neuroinformatics, 2018
Alzheimer's Disease (AD) is the most common neuro-degenerative disorder in the elderly that leads to dementia. The hallmark of AD is senile lesions made by abnormal aggregation of amyloid beta in extracellular space of brain.
Javaria Ashraf, Jamil Ahmad, Amjad Ali, Zaheer Ul-Haq   +3 more
doaj   +1 more source

Learning Petri net models of non-linear gene interactions [PDF]

, 2005
Understanding how an individual's genetic make-up influences their risk of disease is a problem of paramount importance. Although machine-learning techniques are able to uncover the relationships between genotype and disease, the problem of automatically
Mayo, Michael
core   +2 more sources

Imatinib decreases germ cell survival and germline stem cell proliferation in rodent testis ex vivo and in vitro

Andrology, EarlyView.
Abstract Background Imatinib and dasatinib are tyrosine kinase inhibitors (TKIs) increasingly used to treat several diseases in both children and adults at fertile age. We have previously shown that imatinib has adverse effects on developing testis, and imatinib‐treated male patients have been reported to have reduced sperm counts.
Anna Eggert, Sini Laasanen, Mirja Nurmio, Aida Wahlgren, Kirsi Jahnukainen, Kim Eerola, Miisael Nieminen, Opeyemi Olotu, Noora Kotaja, Juho‐Antti Mäkelä, Jorma Toppari   +10 more
wiley   +1 more source

Biodiversity in mountain soils above the treeline

Biological Reviews, EarlyView.
ABSTRACT Biological diversity in mountain ecosystems has been increasingly studied over the last decade. This is also the case for mountain soils, but no study to date has provided an overall synthesis of the current state of knowledge. Here we fill this gap with a first global analysis of published research on cryptogams, microorganisms, and fauna in ...
Nadine Praeg, Michael Steinwandter, Davnah Urbach, Mark A. Snethlage, Rodrigo P. Alves, Martha E. Apple, Peter Bilovitz, Andrea J. Britton, Estelle P. Bruni, Ting‐Wen Chen, Kenneth Dumack, Fernando Fernandez‐Mendoza, Michele Freppaz, Beat Frey, Nathalie Fromin, Stefan Geisen, Martin Grube, Elia Guariento, Antoine Guisan, Qiao‐Qiao Ji, Juan J. Jiménez, Stefanie Maier, Lucie A. Malard, Maria A. Minor, Cowan C. Mc Lean, Edward A. D. Mitchell, Thomas Peham, Roberto Pizzolotto, Andy F. S. Taylor, Philippe Vernon, Johan J. van Tol, Donghui Wu, Yunga Wu, Zhijing Xie, Bettina Weber, Paul Illmer, Julia Seeber   +36 more
wiley   +1 more source

Assessment of the Availability of an Offshore Installation by Stochastic Petri Net Modeling

Communications, 2014
The purpose of this article is to illustrate the combination of stochastic Petri nets and Monte Carlo simulation approach for the evaluation of the production availability of a multi-state, multi-output offshore installation with operational loops.
Radim Bris
doaj   +1 more source

Evolution of gene expression across brain regions in behaviourally divergent deer mice

Molecular Ecology, EarlyView.
Abstract The evolution of innate behaviours is ultimately due to genetic variation likely acting in the nervous system. Gene regulation may be particularly important because it can evolve in a modular brain‐region specific fashion through the concerted action of cis‐ and trans‐regulatory changes.
Andreas F. Kautt, Jenny Chen, Caitlin L. Lewarch, Caroline Hu, Kyle Turner, Jean‐Marc Lassance, Felix Baier, Nicole L. Bedford, Andres Bendesky, Hopi E. Hoekstra   +9 more
wiley   +1 more source

Hybrid performance modelling of opportunistic networks [PDF]

, 2012
We demonstrate the modelling of opportunistic networks using the process algebra stochastic HYPE. Network traffic is modelled as continuous flows, contact between nodes in the network is modelled stochastically, and instantaneous decisions are modelled ...
Bortolussi, Luca, Galpin, Vashti, Hillston, Jane   +2 more
core   +3 more sources

The Roles of Plasticity and Selection in Rapid Phenotypic Changes at the Pacific Oyster Invasion Front in Europe

Molecular Ecology, EarlyView.
ABSTRACT Invasive species present significant management challenges worldwide due to their ability to rapidly adapt to novel environments. The Pacific oyster Crassostrea gigas, a globally distributed invasive species, arrived in western Sweden in 2006 but has not yet colonised the low salinity waters of the Baltic Sea, presumably because low salinities
Alexandra Kinnby, Chloé Robert, Jonathan N. Havenhand, Göran Broström, Luc Bussière, Pierre De Wit   +5 more
wiley   +1 more source

Resources Modulate Developmental Shifts but Not Infection Tolerance Upon Co‐Infection in an Insect System

Molecular Ecology, EarlyView.
ABSTRACT Energetic resources within organisms fuel both parasite growth and immune responses against them, but it is unclear whether energy allocation is sufficient to explain changes in infection outcomes under the threat of multiple parasites. We manipulated diet in flour beetles (Tribolium confusum) infected with two natural parasites and used a ...
Nora K. E. Schulz, Danial Asgari, Siqin Liu, Stephanie S. L. Birnbaum, Alissa M. Williams, Arun Prakash, Ann T. Tate   +6 more
wiley   +1 more source

Fluidification of Stochastic Petri Net by Non Linear Timed Continuous Petri Net

, 2017
Reliability analysis is often based on stochastic discrete event models like Markov models or stochastic Petri nets. For complex dynamical systems with numerous components, analytical expressions of the steady state are tedious to work out because of the
N. E. Akchioui
semanticscholar   +1 more source