Advanced Science, EarlyView.This study presents the de novo design and directed evolution of a mirror‐image D‐protein inhibitor targeting human interleukin‐4 (IL‐4). The engineered molecule exhibits nanomolar binding affinity for IL‐4 and effectively inhibits IL‐4–mediated signaling.
Liqing Xu +7 more
wiley +1 more source
A stochastic programming approach for dynamic allocation of bed capacity and assignment of patients to collaborating hospitals during pandemic outbreaks. [PDF]
Health Care Manag SciBaas S +3 more
europepmc +1 more source
Size‐Modulated Mesoderm‐Endoderm Divergence and Myocardial Cavitation in Micropatterned Cardioids
Advanced Science, EarlyView.Micropatterned cardioids, CRISPR‐engineered reporter hiPSCs, deep‐tissue imaging, and single‐cell RNA sequencing are integrated to model mesoderm‐endoderm co‐development. Heart‐foregut crosstalk promotes single large cavitation inside cardioids, resembling early heart chamber formation. ABSTRACT The human heart, originating from the splanchnic mesoderm,
Plansky Hoang +12 more
wiley +1 more source
A Monte Carlo-Based Framework for Two-Stage Stochastic Programming: Application to Bond Portfolio Optimization. [PDF]
Entropy (Basel)Albaqami H, Mrad M, Gharbi A, Subasi MM.
europepmc +1 more source
Optimization of Ecological Water Supplement Scheme for Improved Suitable Habitat Area for Rare Migratory Birds in Nature Reserves Using Interval-Parameter Fuzzy Two-Stage Stochastic Programming Model. [PDF]
Int J Environ Res Public Health, 2020 Liao X, Meng C, Ren Z, Zhao W.
europepmc +1 more source
Advanced Science, EarlyView.A healthy gut barrier shields underlying fibroblasts from luminal shear forces, illustrating that “good fences make good neighbors.” Barrier damage exposes fibroblasts to shear stress, inducing cell death and the emergence of stress‐adapted, profibrotic fibroblasts. Sustained shear exposure promotes the formation of stiff aggregates of mechanoadapative
Soyoun Min +6 more
wiley +1 more source
A stochastic programming model for trauma hospital network expansion considering rural communities and COVID-19. [PDF]
Health Care Manag SciPérez E +3 more
europepmc +1 more source
Advanced Science, EarlyView.Geometry and connectivity are complementary structures, which have demonstrated their ability to represent the brain's functional activity. This study evaluates geometric and connectome eigenmodes as biologically informed constraints for EEG source localization.
Pok Him Siu +6 more
wiley +1 more source
Hybrid quantum-classical stochastic programming for co-planning 5G base stations and photovoltaic power stations in urban communities. [PDF]
Sci RepXu Y, Han X, Luo R, Li Z.
europepmc +1 more source
Advanced Science, EarlyView.This study reveals that maternal antibiotic exposure prior to conception disrupts intergenerational gut microbial succession. By enhancing maternal‐offspring microbial transmission, altering microbial developmental trajectories and increasing selective pressures during community assembly, these disturbances lead to persistent gut mucosal immaturity and
Yuzhu Chen +8 more
wiley +1 more source