Results 141 to 150 of about 21,348 (275)
Advanced Science, EarlyView.TarPass provides a rigorous benchmark for target‐aware de novo molecular generation by jointly evaluating protein‐ligand interactions, molecular plausibility, and drug‐likeness on 18 well‐studied targets. Results show that current models often fail to consistently surpass random baseline in target‐specific enrichment, while post hoc multi‐tier virtual ...
Rui Qin +11 more
wiley +1 more source
Advanced Science, EarlyView.Engineered extracellular vesicles displaying Ephrin‐B2 selectively target Ephrin‐B4–expressing ovarian cancer cells, enabling precise delivery in patient‐derived models. This scalable bio‐manufacturing platform reveals a versatile strategy to exploit Ephrin signaling for highly specific therapeutic payload delivery and motivates exploration of tailored
Nihar Godbole +17 more
wiley +1 more source
Dynamic network model of banking system stability [PDF]
, 2015 This paper presents a dynamic model of banking interactions, which uses interbank connections to study the stability of the banking system. The dynamic model extends previous work on network models of the banking system taking inspiration from large ...
Wei, Mengyang +3 more
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Advanced Science, EarlyView.A “de‐doping” strategy positions mixed protonic–electronic conductors (MPECs) as adaptive neuromorphic platforms with dynamically tunable transport. Co‐BAND achieves giant conductivity modulation (>106) and chemically tunable synaptic plasticity. Analogous to biological neuromodulation, solvent vapors dynamically reprogram the device's learning rules ...
Kwangmin Park +10 more
wiley +1 more source
Stochastic Optimal Growth with Bounded or Unbounded Utility and with Bounded or Unbounded Shocks [PDF]
This paper studies a one-sector stochastic optimal growth model with i.i.d. productivity shocks in which utility is allowed to be bounded or unbounded, the shocks are allowed to be bounded or unbounded, and the production function is not required to ...
Takashi Kamihigashi
core
Transposase‐Assisted Donor Tethering Boosts Large‐Fragment HDR in Plants
Advanced Science, EarlyView.A transposase‐assisted donor tethering strategy is developed to enhance homology‐directed repair in plants. By recruiting donor DNA to double‐strand breaks and synergizing with repair pathway reprogramming and transcription‐coupled donor design, this system markedly improves large‐fragment targeted insertion efficiency, providing a robust platform for ...
Sha Wei +8 more
wiley +1 more source
Advanced Science, EarlyView.High‐throughput quantum‐mechanical simulations reveal that amorphous carbon undergoes shear‐driven structural transformation into aromatic, graphene‐like interfaces. This mechanochemical process is governed by dopant chemistry: dopants with valency less than four promote the emergence of superlow‐friction amorphous graphene, whereas tetra‐valent ...
Takuya Kuwahara +4 more
wiley +1 more source
reservedStochastic filtering theory is concerned with the reconstruction of an instance of a stochastic process, called signal process, knowing some partial observations on it, given by the so-called observation process.
VIANELLO, LINDA
core
On the local dynamics of polynomial difference equations with fading stochastic perturbations
, 2010 We examine the stability-instability behaviour of a polynomial difference equa- tion with state-independent, asymptotically fading stochastic perturbations. We find that the set of initial values can be partitioned into a stability region, an instability
Kelly, C. +3 more
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