Results 91 to 100 of about 4,001,987 (298)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Research Progress on Cuttings of Malus Rootstock Resources in China

open access: yesHorticulturae
Apple (Malus Mill.) is one of the most important fruits in China, and it boasts the world’s largest cultivation area and yield. It needs to be grafted onto rootstocks to maintain a variety of characteristics. China has many apple rootstock resources that
Dajiang Wang   +10 more
doaj   +1 more source

ANALISIS PENGARUH RETURN ON ASSETS (ROA), RETURN ON EQUITY (ROE) DAN NET PROFIT MARGIN (NPM) TERHADAP RETURN SAHAM PADA PERUSAHAAN MANUFAKTUR YANG TERDAFTAR DI BURSA EFEK INDONESIA [PDF]

open access: yes, 2009
Title "The Analysis Return on assets (ROA), return on equity (ROE), net profit margin (NPM) of the return on the stock of manufacturing companies listed in Indonesia Stock Exchange." This research aims to influence the performance tester manufacturing ...
Mariyana, Rina
core  

Modeling record-breaking stock prices

open access: yes, 2013
We study the statistics of record-breaking events in daily stock prices of 366 stocks from the Standard and Poors 500 stock index. Both the record events in the daily stock prices themselves and the records in the daily returns are discussed.
Wergen, Gregor
core   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

open access: yesFEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji   +2 more
wiley   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

open access: yesFEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer   +7 more
wiley   +1 more source

Terörizmin Hisse Senedi Piyasasındaki İşlem Adedi Üzerindeki Etkisi: Türkiye Örneği

open access: yesSelçuk Üniversitesi Sosyal Bilimler Enstitüsü Dergisi, 2019
Son yıllar terör olaylarında çarpıcı bir artışa şahitlik etmektedir. Bu tür olayların getirileri düşürerek ve volatiliteleri artırarak hisse senedi piyasaları üzerinde yıkıcı bir etki yaratmaları beklenir.
Mustafa Yıldırım, Fatma Küçük
doaj  

Current state of ichthyofauna and use of aquatic bioresources in the Khrystoforivske Reservoir (Bokovenka River, Dnipro basin)

open access: yesRibogospodarsʹka Nauka Ukraïni
Purpose. To investigate the current state of the ichthyofauna in the Khrystoforivske Reservoir (nearshore and pelagic fish communities), the peculiarities of the distribution of fish communities, their abundance, as well as bioproduction capabilities ...
D. Kobyakov   +3 more
doaj   +1 more source

Stock returns, volume and stock price volatility : An empirical firm-level analysis [PDF]

open access: yes, 2002
This paper examines the relation between stock returns and stock market volatility in an autoregressive conditional heteroskedasticity model framework.
Jurgen Schraepen
core   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

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