Results 51 to 60 of about 3,966,135 (297)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

An ALE Meta-Analysis on Investment Decision-Making

open access: yesBrain Sciences, 2021
It is claimed that investment decision-making should rely on rational analyses based on facts and not emotions. However, trying to make money out of market forecasts can trigger all types of emotional responses.
Elena Ortiz-Teran   +2 more
doaj   +1 more source

Social Intelligence Design in Ambient Intelligence [PDF]

open access: yes, 2009
This Special Issue of AI and Society contains a selection of papers presented at the 6th Social Intelligence Design Workshop held at ITC-irst, Povo (Trento, Italy) in July 2007.
Nijholt, A.   +2 more
core   +3 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

A Review of the Research on Reproductive Biology of Turkish Marine Fishes

open access: yesÇanakkale Onsekiz Mart University Journal of Marine Sciences and Fisheries, 2021
The teleost fish stocks distributed in Turkish seas are threatened due to overfishing, pollution, global warming and increasing food competition. There is a need to provide scientific knowledge on reproductive traits of commercial species in order to ...
İsmail Burak DABAN
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

THEORETICAL-METHODOLOGICAL IMPORTANCE OF INTERNATIONAL LISTING OF STOCKS FOR INVESTORS AND EMITENTS

open access: yesВісник Київського національного університету імені Тараса Шевченка. Серія Економіка, 2018
In the conditions of globalization of the economic environment, the integration processes of the international capital markets are intensifying, which envisages the possibility of placing securities in foreign markets.
I. Mazur, R. Sazonov
doaj   +1 more source

Titanothere remains from the Sespe of California [PDF]

open access: yes, 1935
Until very recently, all occurrences of American titanotheres have been known from either Eocene or lower Oligocene horizons of the Rocky Mountains and western Great Plains. Absence of any trace of these mammals in Tertiary deposits located in the region
Stock, Chester
core  

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

open access: yesMolecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed   +10 more
wiley   +1 more source

Comprehensive Transcriptome and Metabolome Analysis of Hemp (Cannabis Sativa L.) in Soil Under NaCl Stress

open access: yesJournal of Natural Fibers, 2023
Planting economic crops in soil with salt imbalances can improve land use efficiency. Hemp, which can be planted in low-salinity soil, is a crop with a very high economic value. To reveal the salt tolerance mechanism of hemp, the leaves of Longma #3 and #
Ming Zhang   +4 more
doaj   +1 more source

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