Results 51 to 60 of about 960,932 (306)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

TAX POLICY AND STOCK PRICES [PDF]

open access: yesNational Tax Journal, 1987
Windfall profits and losses accrue to investors only when expected after-tax returns or discount rates change, and major tax policy shifts are likely to alter these variables. This study introduces a cashflow valuation model for estimating the windfalls to owners of U.S. nonfinancial corporations caused by the enactment of tax changes.
Thomas Downs, Patric H. Hendershott
openaire   +1 more source

Molecular cancer prevention: Intercepting disease

open access: yesMolecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco   +2 more
wiley   +1 more source

The Effect of Current Ratio and Total Assets Turnover on Stock Prices and Return On Assets as Intervening Variables

open access: yesAt-Tadbir: Jurnal Ilmiah Manajemen, 2023
This study aims to determine the effect of the current ratio (CR) and total assets turnover (TAT) on stock prices and return on assets (ROA) as intervening variables in Hotels, Restaurants, and Tourism Companies during the Covid-19 Pandemic. This type of
Heny Ratnaningtyas, Nurbaeti Nurbaeti
doaj   +1 more source

Stock Prices and Economic News [PDF]

open access: yesThe Journal of Business, 1985
This paper examines the daily response of stock prices to announcements about the money supply, inflation, real economic activity, and the discountrate. Except for the discount rate, survey data on market participants' expectations of these announcements are used to identify the unexpected component of the announcements in order to test the efficient ...
Pearce, Douglas K, Roley, V Vance
openaire   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

Perubahan Harga Saham Perusahaan Tekstil dan Garmen di Indonesia

open access: yesJurnal Ekonomi Modernisasi, 2018
The purpose of this study was to determine the implications of net profit margins, debt to equity ratio and quick ratio to stock prices. The population used is various textile and garment subsector industries in the Indonesia Stock Exchange in 2011-2015.
Sriyono Sriyono, Aminatus Solihah
doaj   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

open access: yesFEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li   +6 more
wiley   +1 more source

Impact of Public Announcements on Stock Prices: Relation between Values of Stock Prices and the Price Changes in Lithuanian Stock Market

open access: yesProcedia - Social and Behavioral Sciences, 2014
AbstractThe previous studies have shown that there is a relation between values of stock prices and the price changes caused by public announcements. Thus the aim of this paper is to examine if the respective relation can be observed in Lithuanian stock market and how this relation is affected by different categories and types of announcements.
Stankevičienė, Jurgita   +1 more
openaire   +2 more sources

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

open access: yesFEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda   +12 more
wiley   +1 more source

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