Results 111 to 120 of about 1,316,843 (310)

Cleavage‐Resistant CYLD Protects Against Autoimmune Hepatitis

open access: yesAdvanced Science, EarlyView.
Proteolytic cleavage of the deubiquitinase CYLD emerges as a critical driver of autoimmune hepatitis. TNFα‐induced CYLD loss in macrophages amplifies S100A9‐triggered MAPK activation, leading to excessive chemokine production and hepatic inflammation. Pharmacological inhibition of MEK signaling effectively attenuates experimental disease, highlighting ...
Han Liu   +13 more
wiley   +1 more source

MicroRNA‐375‐3p Targets Fatty Acid Synthase and Relish to Regulate Energy Allocation During Pupal Metamorphosis and Starvation

open access: yesAdvanced Science, EarlyView.
During pupal metamorphosis and starvation, elevated 20‐hydroxyecdysone (20E) and suppressed insulin trigger Forkhead box O (FOXO) nuclear translocation, enhancing miR‐375‐3p expression. This downregulates fatty acid synthase (FASN) and Relish, promoting lipid breakdown for energy while prioritizing antioxidant responses over immune functions to support
Peng Chen   +10 more
wiley   +1 more source

DAMPAK PENGUMUMAN STOCK SPLIT TERHADAP RETURN, VARIABILITAS TINGKAT KEUNTUNGAN DAN AKTIVITAS VOLUME PERDAGANGAN SAHAM (Studi Pada Perusahaan Manufaktur yang terdaftar di BEJ Tahun 1997-1999)

open access: yesWacana: Jurnal Sosial dan Humaniora, 2012
ABSTRAK   Penelitian ini dilakukan atas dasar terjadinya gelombang stock split yang melanda BEJ pada periode 1997-1999 menyusul terjadinya krisis moneter, ekonomi dan politik.
TIWI NURJANNATI UTAMI   +2 more
doaj  

The Conditional Relationship Between Portfolio Beta and Return: Evidence from Latin America [PDF]

open access: yes
Using the approach of Pettengill et al. (1995), we analyze the un-conditional versus conditional cross-sectional CAPM relationship between portfolio beta-risk and return in the Argentinean, Brazilian, Chilean, and Mexican stock markets.
Eduardo Sandoval, Rodrigo Saens
core  

Engineered GM1 Intersects Between Mitochondrial and Synaptic Pathways to Ameliorate ALS Pathology

open access: yesAdvanced Science, EarlyView.
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease driven by genetic and molecular disruptions affecting energy balance, protein homeostasis, and stress responses in nerve cells. Studies using human and rodent models identified convergent defects in mitochondria and synaptic function.
Federica Pilotto   +11 more
wiley   +1 more source

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