Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Relationship between Capital Structure and Economic Performance Separated by Ownership in Listed Companies in Tehran Stock Exchange [PDF]
International Journal of Management, Accounting and Economics, 2016 The main purpose of this research is to study the relationship between capital structure and firms’ economic performance separated by ownership.
Mostafa Hosseinzadeh +3 more
doaj
The Relationship Between Capital Structure and Ownership Structure [PDF]
مجله دانش حسابداری, 2011 This research studies the relationship between capital structure and ownership arrangements in companies listed in Tehran Stock Exchange in a descriptive-correlative inquiry.
Gholam Hosein Asadi +2 more
doaj +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Reviewing the Relationship between Capital Structure Policies and the Life Cycle of Listed Companies in Tehran Stock Exchange [PDF]
International Journal of Management, Accounting and Economics, 2014 This study was conducted to investigate the relationship between capital structure policies and the lifecycle of listed companies in Tehran Stock Exchange.
Amir Motahedin, Ehsan Mirmostafaee
doaj
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Investigating the Effects of Ownership Structure on The Performance of the Companies Accepted in the Tehran Stock Exchange [PDF]
بررسیهای حسابداری و حسابرسی, 2009 This study is an attempt to investigate the effects of ownership structure on the performance of the accepted companies in the Tehran Stock Exchange. For testing the hypotheses, the statistical "panel data" technique was employed.
محمد نمازی +1 more
doaj
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Alternative stock structure hypotheses for the southern African hake resources [PDF]
, 2016 This document summarises alternative stock structure hypotheses for the southern African hakes. The alternatives put forward could apply to either M. capensis or M. paradoxus.
Butterworth, Doug S +1 more
core
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source