Results 41 to 50 of about 781,620 (242)
Optimized Lipid Nanoparticles with Tail‐Modified Ionizable Lipids for Safer mRNA Delivery
Advanced Science, EarlyView.Systematic engineering of hydrophobic tail architecture in vitamin B5‐derived ionizable lipids establishes a comprehensive structure–activity relationship framework for mRNA delivery. Combined lipidtail and formulation optimization identifies TM1‐OPT3‐C, a lipid nanoparticle platform that improves efficacy–safety balance through efficient mRNA delivery,
Seo‐Hyeon Bae +27 more
wiley +1 more source
Applied SciencesShort-chain chlorinated paraffins (SCCPs) are ubiquitous environmental pollutants that have been detected in various human tissues and organs. Based on the results of numerous studies indicating that exposure to environmentally relevant doses could ...
Jelena Čulin
doaj +1 more source
Людина і довкілля: Проблеми неоекології, 2021 Purpose. The estimating the amount of accumulation of waste containing Persistent Organic Pollutants (POPs) and state of the management system for this waste in Odesa region. Methods.
V. I. Mykhailenko, T. A. Safranov
doaj +1 more source
Advanced Science, EarlyView.Sterol engineering enables precise control of mRNA lipid nanoparticles by tuning membrane organization. Replacing cholesterol with bile acid‐derived sterols redirects protein expression from the liver to the spleen. Notably, CA‐20 LNP enhances antigen‐specific immune responses while exhibiting a favorable safety profile, highlighting sterols as a ...
Sanghyuk Jeon +27 more
wiley +1 more source
Emerging Contaminants, 2017 A report that reviews Arctic contaminants that are not currently regulated as persistent organic pollutants (POPs) under international treaties was recently published by the Arctic Monitoring and Assessment Programme (AMAP).
Efstathios Reppas-Chrysovitsinos +2 more
doaj +1 more source
International legal regulation of the right to adequate environment [PDF]
Međunarodni Problemi, 2003 The article deals with some key issues concerning the evolution of the concept of the right to adequate environment. The evolution took several decades to reach the present state in which it is obvious that the right has been accepted as one of the so ...
Vukasović Vid
doaj +1 more source
Advanced Science, EarlyView.Pasta is a transcriptomic aging clock built on an age‐shift learning framework and trained on 17 000 samples across 21 datasets. It accurately predicts relative biological age across tissues, platforms, and species, captures stemness‐to‐senescence transitions, and identifies age‐modulatory perturbations.
Jérôme Salignon +6 more
wiley +1 more source
Hepatology, EarlyView., 2022 Natural history of liver disease in a large international cohort of children with Alagille syndrome: Results from the GALA study. Abstract Background and Aims Alagille syndrome (ALGS) is a multisystem disorder, characterized by cholestasis. Existing outcome data are largely derived from tertiary centers, and real‐world data are lacking.
Shannon M. Vandriel +93 more
wiley +1 more source
Environmental Sciences Europe, 2018 Persistent plastics, with an estimated lifetime for degradation of hundreds of years in marine conditions, can break up into micro- and nanoplastics over shorter timescales, thus facilitating their uptake by marine biota throughout the food chain.
Frederic Gallo +7 more
doaj +1 more source
Data‐Driven Discovery of Unconventional Antiferromagnets
Advanced Science, EarlyView.A high‐throughput workflow that combines the physics‐informed pre‐screening, high‐throughput exchange calculations, Luttinger‐Tisza analysis and symmetry classification is established for accurate identification of unconventional antiferromagnets from the broad structural database.
Qirui Cui +3 more
wiley +1 more source