Results 41 to 50 of about 621,617 (245)

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source

Comparison of 15–20 mmHg versus 20–30 mmHg Compression Stockings in Reducing Occupational Oedema in Standing and Seated Healthy Individuals

International Journal of Vascular Medicine, 2018
Background. Elastic compression stockings (ECS) are effective in preventing and reducing occupational edema (OE), but the optimal pressure according to the prevalent working position during the day is still controversial. Objective.
Cleusa Ema Quilici Belczak, José Maria Pereira de Godoy, Amélia Cristina Seidel, Sergio Belczak, Rubiana Neves Ramos, Roberto Augusto Caffaro   +5 more
doaj   +1 more source

Compression hosiery to avoid post-thrombotic syndrome (CHAPS) protocol for a randomised controlled trial (ISRCTN73041168)

BMJ Open, 2021
Introduction Up to 50% of patients develop post-thrombotic syndrome (PTS) after an above knee deep vein thrombosis (DVT). The aim of the study was to determine the effect of graduated compression stockings in preventing PTS after DVT.Methods and analysis
John Norrie, Rebecca Lawton, Nicky Cullum, Joseph Shalhoub, Beverley J Hunt, Robert Horne, Andrew Bradbury, David Epstein, Manjit Gohel, A H Davies, Ankur Thapar, Laura Burgess   +11 more
doaj   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Beta1 subunits enable fentanyl‐induced BK channel activation and opioid regulation of cerebral artery diameter

FEBS Open Bio, EarlyView.
During the current opioid crisis, the majority of overdose deaths are attributed to ultra‐potent synthetic opioids, such as fentanyl. While fentanyl exerts its action via opioid receptors, we propose that potassium channels in the brain blood vessels may also sense fentanyl.
Shiwani Thapa, Mohammed Nooh, Akhil Geddati, Alex Dopico, Anna N. Bukiya   +4 more
wiley   +1 more source

Biophysical characteristics of medical compression stockings

, 2007
Summary Aim: Haemodynamic effectivity of 13 compression stockings in correlation with its physical characteristics. Patients, methods: In a prospective study, 42 patients in clinical stage C1–4 were examined with dynamic mercury strain gauge ...
A. Ströhn, M. Jünger, H. M. Häfner
core   +1 more source

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

FEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao, Leonie Meyer, Madita Braun, Katharina Otte, Celine Bitter, Maite Pawlik, Hartmann Raifer, Frederik Helmprobst, Axel Pagenstecher, Hans Urban, Michael C. Burger, Michael W. Ronellenfitsch, Joachim P. Steinbach, Jarmila Jedelská, Shamim Bagheri, Behrooz H. Yousefi, Pietro Di Fazio, Markus Luster, Andreas H. Mahnken, Andreas Neubauer, Andreas Burchert, Christopher Nimsky, Jörg W. Bartsch, Tillmann Rusch   +23 more
wiley   +1 more source

Sequential Compression Devices Versus Graduated Compression Stockings

, 2016
This evidence-based practice research compares the outcomes of sequential compression devices and graduated compression stockings on the prevention of blood-clot related complications in the ...
Heisner, Brooke
core   +1 more source

The level of awareness and the attitude of patients recommended for use of compression stockings in Turkish society, and investigation of the factors affecting their use

Patient Preference and Adherence, 2018
Şinasi Manduz,1 Fatih Ada,1 Yusuf Ada2 1Cardiovascular Surgery Department, Cumhuriyet University School of Medicine, Sivas, Turkey; 2Department of Business Administration, Cumhuriyet University Faculty of Economics and Administrative Sciences, Sivas ...
Manduz Ş, Ada F, Ada Y
doaj  

Graded compression stockings in elective orthopaedic surgery

, 2000
We recruited 89 patients who had hip or knee replacements to assess the performance of below-knee graded compression stockings. The pressure gradients generated by the stockings were measured and all patients had venography of the ipsilateral leg.
A. C. W. Hui, P. J. Gregg, A. J. Best, R. Bhatt, S. Williams, A. Crozier   +5 more
core   +1 more source