Results 101 to 110 of about 431,587 (304)

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

Optimization method of investment package based on Markowitz portfolio theory

Вестник Дагестанского государственного технического университета: Технические науки
Objective. The aim of the study is to implement and evaluate the optimization method based on the Markowitz portfolio theory. Method. The model is built using the Python programming language and the necessary libraries.
A. D. Baydalin
doaj   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

An Integrated Approach to Stock Selection and Ranking: Combining Shannon Entropy Technique, DEA, and Inverse DEA

IEEE Access
This study proposes a novel, integrated framework that combines Shannon Entropy Technique (SET), Data Envelopment Analysis (DEA), and Inverse DEA (IDEA) for the objective evaluation and ranking of equities, with a case application to the tourism sector ...
Temitope Olubanjo Kehinde, Sai-Ho Chung, Oludolapo A. Olanrewaju   +2 more
doaj   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Elevated Connectivity During Language Processing Is Associated With Cognitive Performance in SeLECTS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Self‐Limited Epilepsy with Centrotemporal Spikes (SeLECTS) is associated with language impairments despite seizures originating in the motor cortex, suggesting aberrant cross‐network interactions. Here we tested whether functional connectivity in SeLECTS during language tasks predicts language performance.
Wendy Qi, Katharine Lee, Kerry C. Nix, Miguel Menchaca, Xiwei Shé, Lorelei Santa Maria, Wei Wu, Zihuai He, Fiona M. Baumer   +8 more
wiley   +1 more source

WHO CAN FISH WHAT AND WHERE: CHILE'S TRADEOFFS IN HIGH SEAS FISHING OF STRADDLING STOCKS [PDF]

Chile has not yet ratified the U.N. 1995 Agreement on straddling/ highly migratory fish stocks. This paper discusses key economic issues at stake from the viewpoint of a coastal state with important stakes in a straddling stock. The Chilean jack mackerel
Pena-Torres, Julio, Basch, Michael, Serra, Rodolfo   +2 more
core  

Increased Soil Soluble Nitrogen Stocks and Decreased Nitrogen Leaching Loss in Rice Paddy Soil by Replacing Nitrogen Fertilizer with Chinese Milk Vetch

Agronomy
Reducing soil nitrogen leaching losses and improving nitrogen-use efficiency with effective fertilization management strategies are extremely important for sustainable agricultural development.
Jing Yang, Wenqi Guo, Chengsen Zhao, Biqing Zhou, Wenhao Yang, Shihe Xing, Fenghua Ding   +6 more
doaj   +1 more source

Comparing the Effect of Semi‐Immersive Virtual Reality, Computerized Cognitive Training, and Traditional Rehabilitation on Cognitive Function in Multiple Sclerosis: A Randomized Clinical Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Cognitive impairment is a common non‐motor symptom in Multiple Sclerosis (MS), negatively affecting autonomy and Quality of Life (QoL). Innovative rehabilitation strategies, such as semi‐immersive virtual reality (VR) and computerized cognitive training (CCT), may offer advantages over traditional cognitive rehabilitation (TCR ...
Maria Grazia Maggio, Desiree Latella, Lilla Bonanno, Paulo Cezar Rocha dos Santos, Marcos Maldonado‐Díaz, Meir Plotnik, Rosaria De Luca, Angelo Quartarone, Rocco Salvatore Calabrò   +8 more
wiley   +1 more source

Stocks as Hedge against Inflation in Pakistan: Evidence from ARDL Approach [PDF]

The paper implements ARDL bounds testing approach to cointegration to explore whether or not stocks are good hedge against inflation in the case of a transition economy such as Pakistan, using annual data for the period 1971 – 2008.
Islam, Faridul, Shahbaz, Muhammad
core