Results 81 to 90 of about 5,062,400 (385)

Molecular Characterization of the Human Stomach Microbiota in Gastric Cancer Patients

Frontiers in Cellular and Infection Microbiology, 2017
Helicobacter pylori (Hp) is the primary cause of gastric cancer but we know little of its relative abundance and other microbes in the stomach, especially at the time of gastric cancer diagnosis. Here we characterized the taxonomic and derived functional
G. Yu, J. Torres, N. Hu, R. Medrano-Guzmán, R. Herrera-Goepfert, M. Humphrys, Lemin Wang, Chaoyu Wang, T. Ding, J. Ravel, P. Taylor, C. Abnet, A. Goldstein   +12 more
semanticscholar   +1 more source

The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1

FEBS Letters, EarlyView.
MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson, Robert Gustafsson Westergren, Ingrid Almlöf, Ann‐Sofie Jemth, Martin Scobie, Ulrika Warpman Berglund, Thomas Helleday, Pål Stenmark   +7 more
wiley   +1 more source

SIMULTANEOUS SURGICAL TREATMENT OF STOMACH CANCER AND JEJUNAL DIVERTICULOSIS

Паёми Сино, 2021
The article presents a case of a combination of stomach cancer and jejunal diverticulosis in a 71-year-old female patient. Stomach cancer was diagnosed preoperatively both clinically and by instrumental (endoscopic and radiological) and ...
R.Z. YULDOSHEV, А.А. KHODZHAMKULOV, D.SH. NURALIEV, D.SH. NURALIEV, A.SH. ABDULLOEV   +4 more
doaj   +1 more source

The cytotoxic Activity of Cucurbitacin E and Busulphan on ovarian and stomach cancer cells in vitro : a comparative study [PDF]

, 1996
A comparative study of the cytotoxicity of cucurbitacin E, a natural product, and busulphan on human ovarian and stomach cell lines was carried out.
Attard, Everaldo, Cuschieri, Alfred, Grixti, Mario, Scicluna-Spiteri, Anthony   +3 more
core  

C‐mannosylation promotes ADAMTS1 activation and secretion in human testicular germ cell tumor NEC8 cells

FEBS Letters, EarlyView.
C‐mannosylation is a unique form of protein glycosylation. In this study, we demonstrated that ADAMTS1 is C‐mannosylated at Trp562 and Trp565 in human testicular germ cell tumor NEC8 cells. We found that C‐mannosylation of ADAMTS1 is essential for its secretion, processing, enzymatic activity, and ability to promote vasculogenic mimicry. These findings
Takato Kobayashi, Takehiro Suzuki, Ryota Kawahara, Natsumi Harai, Naoshi Dohmae, Siro Simizu   +5 more
wiley   +1 more source

Поширеність раку шлунка в сім’ях із гострою лейкемією в потомстві [PDF]

, 2010
Досліджено частку захворювань на рак шлунка (РШ) у 192 родинах, що мали дітей із гострою лейкемією. Встановлено, що в цій групі частота РШ (28 родин; 14,6%; від 1 до 4 випадків РШ на родину) достовірно перевищувала таку в контрольній групі — 192 ...
Гнатейко, О.З., Кіцера, Н.І., Осадчук, З.В., Поліщук, Р.С.   +3 more
core  

Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes

FEBS Letters, EarlyView.
Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley   +1 more source

Bayesian joint spatio-temporal analysis of multiple diseases [PDF]

, 2019
In this paper we propose a Bayesian hierarchical spatio-temporal model for the joint analysis of multiple diseases which includes specific and shared spatial and temporal effects.
Fernández-Navarro, Pablo, Gómez-Rubio, Virgilio, López-Abente, Gonzalo, Palmí-Perales, Francisco, Ramis-Prieto, Rebeca   +4 more
core  

Fat transforms ascorbic acid from inhibiting to promoting acid-catalysed N-nitrosation [PDF]

, 2007
<b>Background</b>: The major potential site of acid nitrosation is the proximal stomach, an anatomical site prone to a rising incidence of metaplasia and adenocarcinoma.
Combet, E., Crozier, A., Iijima, K., McColl, K.E.L., Mullen, W., Paterson, S., Preston, T., Winter, J.   +7 more
core   +2 more sources

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source