Results 41 to 50 of about 253,827 (253)

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Regenerative processes during model gastric ulcer in laboratory rats when using Humilid

Theoretical and Applied Veterinary Medicine, 2021
A gastric ulcer caused by non-steroidal anti-inflammatory drugs is the second most common after Helicobacter pylori in both humane and veterinary medicine. The urgent need to find alternative drugs that had a minimum number of side effects led to the use
A. Y. Lisna, L. M. Stepchenko
doaj   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Effect of Aqueous Extract of Pleurotus Tuber-Regium on Ethanol Induced Peptic Ulcer in Male Wistar Rats [PDF]

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2023
Background and Objective: There is increasing desire for pleiotropic plant-based remedies for the treatment of peptic ulcer disease due to its prevalence and the challenges associated with existing therapies.
AC Onuegbu, CC Nworgu, DC Ikwuka, DB Adeniyi, OK Okafor, JU Uzoigwe, M Nweke, ZN Uzoigwe, D Nwachukwu   +8 more
doaj   +2 more sources

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Аctivity of stomach secretory glands and the nitrergic mechanisms of their regulatiоn under the condition of the adrenalin ulcer simulation [PDF]

, 2009
Participating of nitrergic link in the regulation of secretory activity in the stomach was investigated in the intact rats under the condition of ulcerous damage in the gastro-duodenal area.
A. I. Rudenko, Razuvaeva, O. V., O. V. Razuvaeva, Murzin, O. B., Rudenko, A. I., O. B. Murzin   +5 more
core   +1 more source

Five‐Year Outcomes of Laparoscopic Sphincter‐Preserving Surgery for Rectal Cancer: A Prospective Study in Elderly Vietnamese Patients

Aging and Cancer, EarlyView.
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho, Quang Le, Ngoc Thach Tran, Van Viet Ung, Loc Vu   +4 more
wiley   +1 more source

Combined endoscopic and laparoscopic approach for palliative resection of metastatic melanoma of the stomach

World Journal of Surgical Oncology, 2006
Background Metastatic tumours of the stomach present a clinical dilemma for the surgeon. Palliative surgical resection can alleviate symptoms and prolong survival in selected patients.
Pritchard SA, Griffiths EA, Date RS, Welch I McL   +3 more
doaj   +1 more source

Evaluation of the results of pH-metry of the stomach in patients with peptic ulcer of the stomach and duodenum under the influence of a physical therapy program

Фізична реабілітація та рекреаційно-оздоровчі технології, 2022
Purpose: to investigate and evaluate the secretory function of the stomach in patients with peptic ulcer of the stomach and duodenum under the influence of the use of a physical therapy program.
Yuliya Kalmykova, Sergey Kalmykov, Daria Okun, Andriі Istomin   +3 more
doaj   +1 more source

Periodic activity of secretory glands of stomach in ulcer erosion of gastro-duodenal zone [PDF]

, 2005
It was fixed, that development of atophanum-carbacholimun ulcer of the gastroduodenal zone invoked various changes of secretory activity of the stomach. The changes directly depend on a progress of pathological process.
Trushenko, A. S., A. I. Rudenko, Rudenko, A. I., Murzin, O. B., O. B. Murzin, A. S. Trushenko   +5 more
core   +1 more source