Results 111 to 120 of about 1,443 (216)

Mechanical Activation of Piezo1 Drives Osteoarthritis Through Kdm5c‐Mediated Epigenetic Silencing

Advanced Science, EarlyView.
Excessive mechanical stress activates Piezo1, triggering Ca2+‐dependent cytoskeletal forces that deform the nucleus and reduce H3K4me3. Kdm5c demethylates H3K4me3 at Col2a1 and Runx3 promoters. Kdm5c knockout rescues degradation. Repurposed telmisartan directly inhibits Kdm5c, blocking this axis and showing disease‐modifying efficacy in mouse OA models
Tianyou Kan, Xuran Li, Han Wang, Lin Sun, Yao Wang, Jiangdong Wu, Junqi Cui, Yiqi Yang, Kai Yuan, Linyang Chu, Liao Wang, Hanjun Li, Mengning Yan, Zhifeng Yu   +13 more
wiley   +1 more source

Facile Fabrication of Low‐Impedance, Highly Conformal Epidermal Electrodes Based on Laser‐Induced Graphene–Silver Nanocomposites

Advanced Science, EarlyView.
A facile laser‐induced graphene–silver nanocomposite strategy enables ultrathin epidermal electrodes with low impedance, high conductivity, and excellent mechanical robustness. The porous LIG–Ag conductive network mechanically interlocked with SEBS provides stable, motion‐resistant biopotential monitoring, enabling high‐fidelity ECG, EMG, and EEG ...
Jiuqiang Li, Senhao Zhang, Kai Guo, Donghai Qiu, Juzhong Zhang, Hongbo Yang, Huanyu Cheng   +6 more
wiley   +1 more source

Quality Thresholds for Angiogenesis Under Acoustic Manipulation in Engineered Vascular Tissues

Advanced Science, EarlyView.
Defined biological and physical quality thresholds achieved through acoustic manipulation regulate cellular alignment and spatial organization, promoting self‐assembling vasculature, extracellular matrix deposition, and angiogenic responses, thereby establishing critical acoustic patterning requirements for engineered vascular tissue development in ...
Oscar O'Dwyer Lancaster‐Jones, Russell Quinn, Niloofar Khoshdel Rad, Kilian Paul, Andrea Frank, Daniela F. Duarte Campos   +5 more
wiley   +1 more source

An Assisting Contact Electrification Strategy for Achieving Self‐Recoverable Mechanoluminescence

Advanced Science, EarlyView.
ABSTRACT Self‐recoverable mechanoluminescence (ML) is a unique property of materials that can stably emit light under repeated stress, enabling new applications in smart sensing, displays, and wearable devices. However, self‐recoverable ML is very rare and only observed in a few active phosphors excited by piezoelectricity or contact electrification ...
Jianwen Zhang, Weiguang Wang, Jinyu Zhou, Jiachi Zhang, Wenxiang Wang, Shanwen Wang, Jing Liu, Haoyang Li, Xianfeng Jin, Chi Zhang, Ziyuan Li, Zhaofeng Wang, Yuhua Wang   +12 more
wiley   +1 more source

Halide Perovskite: A Rich Source of Thermal Insulator

Advanced Science, EarlyView.
Halide perovskites exhibit ultralow thermal conductivity driven by intrinsic lattice softness and strong anharmonicity, falling below conventional defect‐engineering limits. Weak metavalent bonding, A‐site rattling, and dynamic octahedral tilting drive phonon scattering to the Ioffe–Regel limit, where wave‐like tunneling replaces particle‐like ...
Haolin Ye, Bangzhi Ge, Yuan Yu, Chongjian Zhou   +3 more
wiley   +1 more source

Molecular and Cellular Hallmarks of Age‐Related Vestibular Hair Cell Degeneration

Advanced Science, EarlyView.
This study utilizes single‐cell RNA‐seq transcriptomes, advanced imaging, and electrophysiology to examine universal and cell‐type‐specific aging signatures of vestibular hair cells. The study shows that impaired hair bundle function is a key driver of age‐related vestibular dysfunction.
Samadhi Kulasooriya, Huizhan Liu, Sarath Vijayakumar, Celia Bloom, Zhenhang Xu, Shu Tu, Benjamin J. Borgmeier, Mi Zhou, Litao Tao, Bechara Kachar, David Z. He   +10 more
wiley   +1 more source

Getting a Handle on Technological Complexity in the Acheulean: Hand-axes Make Excellent High-Energy Hafted Woodworking Tools

EXARC Journal
Reconstructing human behavioural complexity from stone tools is a primary concern for the Palaeolithic archaeologist. Two nested challenges exist in this reconstruction.
Christopher Scott, Karl Lee
doaj  

Longitudinal Single‐Axon‐Resolution Imaging of Peripheral Nerve Injury Response in Mice Using an Optical Window Implant

Advanced Science, EarlyView.
A minimally invasive optical window enables stable, long‐term imaging of peripheral nerves in vivo at single‐axon resolution. Dynamic processes of degeneration, regeneration, and cellular remodeling are visualized across multiple time scales within the same nerve region, providing a unique platform to study a variety of anatomical and molecular events ...
Igor D. Luzhansky, Emma Anisman, Ron Perez, Sophia Zhang, Morgan Hoffman, Daniel Hunter, Abigail Cherian, Jevon Bonner, Emilia Feria, Ahmed Ahmed, Muneeb Malik, Junwei Du, Leland C. Sudlow, David M. Brogan, Matthew D. Wood, Mikhail Y. Berezin   +15 more
wiley   +1 more source

CALB2 is a Mechanoresistance Gene in Metastatic Prostate Cancer

Advanced Science, EarlyView.
Prostate cancer cell lines of differing origins were cultured over many passages while being subjected to semi‐lethal levels of fluid shear stress, representing the harsh mechanical environment these cells are subjected to in the circulation during the process of distant metastasis.
Abigail R. Fabiano, Allen C. Luo, Paul Taufalele, Jenna A. Dombroski, Ehsan Aalaei, Schyler J. Rowland, Melissa S. Cantú, Alexandria T. Carter, Samantha V. Knoblauch, Cynthia A. Reinhart‐King, Michael R. King   +10 more
wiley   +1 more source

Spatially Organized Human Ovarian Spheroids Instruct Endometrial Morphogenesis

Advanced Science, EarlyView.
A spatially organized human follicle‐like spheroid (SPHEGaT) composed of granulosa cells (GCs) and stromal‐derived theca‐like cells (TLCs) establishes sustained steroidogenesis in vitro. When co‐cultured with human endometrial organoids (EMOs), estradiol (E2) and progesterone (P4) exchange induces secretory/progesterone‐responsive differentiation ...
Maria João Sousa, Silke De Vriendt, Lixian Liu, Thalles Fernando Rocha Ruiz, Hugo Vankelecom, Christiani Andrade Amorim   +5 more
wiley   +1 more source