Results 41 to 50 of about 190,915 (301)

Noua … corpora: New Bodies and Gendered Patterns in the Metamorphoses

open access: yesDictynna, 2020
This article explores metamorphic outcomes in Ovid’s Metamorphoses. While the poem may be steeped in constant mutability, for the most part gender emerges as a surprisingly static feature, and one that carries remarkable weight also when read beside the ...
Alison Sharrock
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

The safety of ureteral stenting with the use of potassium citrate for management of renal uric acid stones

open access: yesUrology Annals, 2020
Objectives: The objective is to evaluate the relative risks of ureteric stents application while managing uric acid stones with potassium citrate in terms of stone encrustations and urinary tract infection (UTI).
Nawaf Abdulaziz Alenezi   +6 more
doaj   +1 more source

Will the smart ship also be the liable ship?: An analysis of the application of liability to the ship [PDF]

open access: yes, 2017
As engineers develop the future of shipping: unmanned ships, and autonomous operating systems, which do not need a master or crew on board, it is asked: 'who shall be held responsible?'.
Stones, H., Stones, Hannah
core  

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

Characterization of the urogenital microbiome in Miniature Schnauzers with and without calcium oxalate urolithiasis

open access: yesJournal of Veterinary Internal Medicine, 2022
Background Calcium oxalate (CaOx) uroliths are common in dogs. Humans with CaOx urolithiasis exhibit alterations of the urinary and urogenital microbiomes that might mediate urolith formation. Detection of urogenital microbes associated with CaOx in dogs
Emily L. Coffey   +5 more
doaj   +1 more source

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