Results 171 to 180 of about 679,191 (389)

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

open access: yesMolecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu   +12 more
wiley   +1 more source

Kinetic characterization of amino acid activation by aminoacyl‐tRNA synthetases using radiolabelled γ‐[32P]ATP

open access: yesFEBS Open Bio, Volume 15, Issue 4, Page 580-586, April 2025.
Activation of amino acids by aminoacyl‐tRNA synthetases can be followed by a modified ATP/PPi exchange assay using radiolabelled γ‐[32P]ATP. The reaction is quenched at certain time points, followed by separation of the product ([32P]PPi) from the substrate (γ‐[32P]ATP) by thin‐layer chromatography (TLC).
Igor Živković   +4 more
wiley   +1 more source

Modeling and Estimation of Vocal Tract and Glottal Source Parameters Using ARMAX-LF Model [PDF]

open access: yesarXiv
Modeling and estimation of the vocal tract and glottal source parameters of vowels from raw speech can be typically done by using the Auto-Regressive with eXogenous input (ARX) model and Liljencrants-Fant (LF) model with an iteration-based estimation approach.
arxiv  

The use of parametric tests in the study of vowel duration cue for voicing in the following word final consonant in Polish english [PDF]

open access: yes, 1990
Chapter TenZadanie pt. „Digitalizacja i udostępnienie w Cyfrowym Repozytorium Uniwersytetu Łódzkiego kolekcji czasopism naukowych wydawanych przez Uniwersytet Łódzki” nr 885/P-DUN/2014 zostało dofinansowane ze środków MNiSW w ramach działalności ...
Waniek-Klimczak, Ewa
core  

NPC1 promotes the progression of hepatocellular carcinoma by mediating the accumulation of neutrophils into the tumor microenvironment

open access: yesFEBS Open Bio, Volume 15, Issue 4, Page 661-673, April 2025.
Compared to normal tissues, NPC1 expression is significantly elevated in hepatocellular carcinoma tissues. Our findings indicate that NPC1 plays a key role in regulating neutrophil recruitment within the tumor, which is a critical factor in the progression of hepatocellular carcinoma and is closely linked to poor patient outcomes.
Songhai Yang   +3 more
wiley   +1 more source

CDK5 interacts with MST2 and modulates the Hippo signalling pathway

open access: yesFEBS Open Bio, Volume 15, Issue 4, Page 647-660, April 2025.
By using a yeast‐two‐hybrid system, immune precipitation and a proteomics approach, we identify a novel interaction between CDK5 and MST2, which modulates the mechano‐sensitive Hippo signalling pathway in a liver tumour cell line. MST2 (STK3) is a major upstream kinase in the Hippo signalling pathway, an evolutionary conserved pathway in regulation of ...
Mehak Passi   +5 more
wiley   +1 more source

Consonance in music -- the Pythagorean approach revisited [PDF]

open access: yesarXiv
The Pythagorean school attributed consonance in music to simplicity of frequency ratios between musical tones. In the last two centuries, the consonance curves developed by Helmholtz, Plompt and Levelt shifted focus to psycho-acoustic considerations in perceiving consonances.
arxiv  

Home - About - Disclaimer - Privacy