Results 181 to 190 of about 679,191 (389)

Purification and characterization of a thermophilic NAD+‐dependent lactate dehydrogenase from Moorella thermoacetica

open access: yesFEBS Open Bio, Volume 15, Issue 5, Page 714-725, May 2025.
The thermophilic acetogenic model organism Moorella thermoacetica can utilize lactate as substrate. The formation of lactate by reduction of pyruvate is energetically favorable, but the reverse reaction, the oxidation of lactate to pyruvate with NAD+ as electron acceptor is challenging.
Florian P. Rosenbaum, Volker Müller
wiley   +1 more source

Intervention procedures for increasing preschool children's interest in and knowledge about reading [PDF]

open access: yes, 1984
Pages numbered 2-50Includes bibliographical references (p. 45-49)Supported in part by the National Institute of Education under contract no.
Mason, Jana M., McCormick, Christine
core  

Pharmacological effects of osimertinib on a chicken chorioallantoic membrane xenograft model with the EGFR exon‐19‐deleted advanced NSCLC mutation

open access: yesFEBS Open Bio, Volume 15, Issue 5, Page 836-855, May 2025.
Osimertinib reduces angiogenesis and PDL1 expression in in ovo tumors, transforming them into ‘cold tumors’ with lower immune activity. Anatomopathological and transcriptomic analyses highlight its therapeutic impact on tumor biology. This study underscores osimertinib's potential to reshape the tumor microenvironment and provides insights into its ...
David Barthélémy   +14 more
wiley   +1 more source

Red blood cells could protect miRNAs from degradation or loss thanks to Argonaute 2 binding

open access: yesFEBS Open Bio, Volume 15, Issue 5, Page 810-821, May 2025.
The present work investigates the presence and the stability of miRNAs into RBCs, both native and engineered. The observed stability is due to the Ago2 bound resulting in minimal RISC. Indeed, if the miRNA‐Ago2 complex is present, miRNAs are protected from release or degradation and they are biologically active. Thus, RBCs can act as miRNA carriers for
Elena Perla   +4 more
wiley   +1 more source

Dysfunctional tetraspanin 7 (TSP‐7) in Caenorhabditis elegans promotes; increases in average life‐ & health‐span, stress‐induced survival and motility

open access: yesFEBS Open Bio, EarlyView.
The C. elegans tetraspanin‐7 (tsp‐7) is a homologue of human CD63, which is a negative regulator of autophagy. The C. elegans strain, tm5761, has a dysfunctional (knockout) tsp‐7 gene. When compared to the wild‐type strain, the tm5761 strain shows increased: life‐ and health‐span; thermotolerance, and stress‐induced locomotion.
Brogan Jones   +2 more
wiley   +1 more source

Words without vowels : phonetic and phonological evidence from Tashlhiyt Berber [PDF]

open access: yes, 2013
This article deals with the Tashlhiyt dialect of Berber (henceforth TB) spoken in the southern part of Morocco. In TB, words may consist entirely of consonants without vowels and sometimes of only voiceless obstruents, e.g. tft#tstt "you rolled it (fem)".
Ridouane, Rachid
core  

Comparative single‐cell transcriptomic profiling of patient‐derived renal carcinoma cells in cellular and animal models of kidney cancer

open access: yesFEBS Open Bio, EarlyView.
We generated and characterized clear cell renal cell carcinoma models using the patient‐derived RCC243 cell line—including cell culture, orthotopic, and metastatic tumors—via single‐cell RNA‐sequencing for comparisons between models and patient tumor datasets.
Richard Huang   +9 more
wiley   +1 more source

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