Results 201 to 210 of about 679,191 (389)

Downregulation of O‐GlcNAcylation enhances etoposide‐induced p53‐mediated apoptosis in HepG2 human liver cancer cells

open access: yesFEBS Open Bio, EarlyView.
Etoposide, a topoisomerase II inhibitor, reduces O‐GlcNAcylation in HepG2 liver cancer cells. Further inhibition of O‐GlcNAc transferase by OSMI‐1 enhanced etoposide‐induced apoptosis, lowering the IC50 for viability and increasing the EC50 for cytotoxicity.
Jaehoon Lee   +5 more
wiley   +1 more source

Variable finals in proto-Sino-Tibetan [PDF]

open access: yes, 2010
This paper concentrates on variable finals, and argues that just as we find a certain amount of both rule-governed and non-rule governed variation in modern languages, in reconstructing Proto-Sino-Tibetan we should recognize the possibility of these ...
LaPolla, Randy J.
core  

Advanced glycation end products promote the release of endothelial cell‐derived mitocytosis

open access: yesFEBS Open Bio, EarlyView.
Under diabetic conditions, AGEs induce mitochondrial damage in HUVECs, activating migrasome‐mediated mitocytosis. Migrasomes encapsulate damaged mitochondria and are released into the extracellular space, facilitating intercellular mitochondrial transfer.
Rong Liu   +6 more
wiley   +1 more source

Consonant Context Effects on Vowel Sensorimotor Adaptation [PDF]

open access: yes, 2014
Speech sensorimotor adaptation is the short-term learning of modified articulator movements evoked through sensory-feedback perturbations. A common experimental method manipulates acoustic parameters, such as formant frequencies, using real time ...
Bernal, Brittany A.   +4 more
core   +1 more source

Co‐expression of HSV‐1 ICP34.5 enhances the expression of gene delivered by self‐amplifying RNA and mitigates its immunogenicity

open access: yesFEBS Open Bio, EarlyView.
ICP34.5 is one of the most important antihost response proteins. The saRNA‐encoding HSV‐1 neurovirulence protein ICP34.5 clearly mediated the eukaryotic initiation factor 2 alpha subunit (eIF2α) dephosphorylation and significant suppression of innate immune responses in vitro, leading to enhanced expression of the saRNA‐encoded gene.
Xuemin Lu   +6 more
wiley   +1 more source

Investigating Causal Cues: Strengthening Spoofed Audio Detection with Human-Discernible Linguistic Features [PDF]

open access: yesarXiv
Several types of spoofed audio, such as mimicry, replay attacks, and deepfakes, have created societal challenges to information integrity. Recently, researchers have worked with sociolinguistics experts to label spoofed audio samples with Expert Defined Linguistic Features (EDLFs) that can be discerned by the human ear: pitch, pause, word-initial and ...
arxiv  

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