Results 81 to 90 of about 624,544 (348)

The production of the English stop voicing contrast by Arab L2 speakers of English

open access: yesIndonesian Journal of Applied Linguistics, 2020
The English voiceless stop /p/ and voiced stop /ɡ/ are absent in the consonant inventory of Arabic. This difference provides a fertile ground for empirical research in L2 speech learning among Arab L2 speakers of English.
Mohd Hilmi Hamzah   +3 more
doaj   +1 more source

Voicing cues in oral stop consonants

open access: yesJournal of Phonetics, 1973
Abstract: The role of various cues in the perception of voicing in postvocalic stops of French was investigated. Twenty subjects took part in a test requiring recognition, from consonants in a syllable [aC], of one of the six oral stops of French, [p], [b], [t], [d], [k] or [g].
Wajskop, Max, Sweerts, Jacqueline
openaire   +2 more sources

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

open access: yesMolecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece   +18 more
wiley   +1 more source

Exceptional nasal-stop inventories

open access: yesCatalan Journal of Linguistics, 2016
This article explores the topic of exceptionality in phonology focusing on nasal-stop inventories. A meticulous survey shows that it is normal for such systems to include at least two anterior units: /m/ and /n/. The finding that the introduction of /ŋ/,
Carlos-Eduardo Piñeros
doaj   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

open access: yesMolecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir   +2 more
wiley   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

open access: yesMolecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia   +9 more
wiley   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

A Generative Study of Phoneme System of Sarhaddi Balochi Dialect of Granchin [PDF]

open access: yesمطالعات زبان‌‌ها و گویش‌های غرب ایران, 2014
Generative linguists are specifically interested in phonology as an important part of the grammar of any language. Generative phonology the beginning of which can be attributed to Chomsky and Halle (1968), has been proposed in terms of specific patterns ...
Abbas Ali Ahangar   +3 more
doaj  

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