Results 91 to 100 of about 4,341 (303)

Emergence of Prevocalic Stop Consonants in Children With Repaired Cleft Palate. [PDF]

open access: yesJ Speech Lang Hear Res, 2021
Zajac DJ   +5 more
europepmc   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

open access: yesMolecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi   +14 more
wiley   +1 more source

Audio from: 'Modeling Voiced Stop Consonants using the 3D Dynamic Digital Waveguide Mesh Vocal Tract Model' [PDF]

open access: yes, 2019
<p>Audio files associated with the paper 'Modeling Voiced Stop Consonants using the 3D Dynamic Digital Waveguide Mesh Vocal Tract Model', presented at the International Congress of Phonetic Sciences 2019, Melbourne, Australia.</p ...
Benjamin V. Tucker   +3 more
core   +1 more source

Phonetic Training and Talker Variability in the Perception of Spanish Stop Consonants

open access: yesLanguages
This study examined how variability in phonetic training input (high vs. low) influences the perception and acquisition of Spanish stop consonants by English-speaking beginners.
Iván Andreu Rascón
doaj   +1 more source

The (morpho)phonology of oral stop consonants in Proto-Tupi-Guarani: open issues, closed issues and new issues [PDF]

open access: yesBoletim do Museu Paraense Emílio Goeldi. Ciências Humanas
This paper provides an account of certain alternations that characterize all conservative Tupi-Guarani (TG) languages. Three processes are reconstructed for Proto-Tupi-Guarani (PTG): pre-vocalic oral stop lenition, pre-consonantal stop deletion, and ...
Fernando O. de Carvalho
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

open access: yesMolecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir   +13 more
wiley   +1 more source

The Importance of Being Onset: Tuscan Lenition and Stops in Coda Position

open access: yesLanguages
This paper examines Gorgia Toscana (GT), a phenomenon of stop lenition observed in Tuscan varieties of Italian. Traditionally, this process has been understood to occur in post-vocalic positions, which, in the native lexicon, corresponds to onset ...
Giuditta Avano, Piero Cossu
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

open access: yesMolecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu   +13 more
wiley   +1 more source

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